Various embodiments include methods and systems for providing sleep clock edge-based global counter synchronization in a multiple-chiplet system. A system-on-a-chip (SoC) may include a first chiplet including a first chiplet global counter subsystem, and a second chiplet including a second chiplet global counter subsystem. The SoC may further include an interface bus communicatively coupling the first chiplet and the second chiplet, and a power management integrated circuit (PMIC) configured to supply a sleep clock to the first chiplet and the second chiplet. The first chiplet may be configured to transmit a global counter synchronization pulse trigger to the second chiplet across the interface bus. The second chiplet may be configured to load a global counter synchronization value into the second chiplet global counter subsystem at a sleep clock synchronization edge of the sleep clock in response to receiving the global counter synchronization pulse trigger.