A system for path selection using vehicle route guidance includes computing device configured to receive a plurality of requests for a plurality of alimentary combinations and a plurality of destinations, wherein each request specifies an alimentary combination of the plurality of alimentary combinations to be assembled by at least an alimentary provider and a destination of the plurality of destinations, compute a projected nutritionally guided order volume using a first machine-learning process, determine a plurality of assembly times, the plurality of assembly times including an assembly time for each alimentary combination, as a function of the nutritionally guided order volume, generate a plurality of predicted routes as a function of the determined assembly times, and pair a predicted route of the plurality of predicted routes with a courier, wherein pairing further pairing, with the courier, the predicted route that optimizes an objective function.