- 专利标题： 5-membered and bicyclic heterocyclic amides as inhibitors of ROCK
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申请号： US17349980申请日： 2021-06-17
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公开(公告)号： US11673886B2公开(公告)日： 2023-06-13
- 发明人: Peter W. Glunz , Vladimir Ladziata , Indawati De Lucca , George O. Tora , Tarun Kumar Maishal , Raghuram Tangirala , Kamalraj Thiyagarajan
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Hong Liu
- 主分类号： C07D417/12
- IPC分类号： C07D417/12 ; C07D401/14 ; C07D403/12 ; C07D417/14 ; C07D471/04 ; C07D495/04 ; C07D519/00 ; C07D491/052
摘要：
The present invention provides compounds of Formula (I):
or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
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