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公开(公告)号：US20190330186A1
公开(公告)日：2019-10-31
申请号：US16309168
申请日：2017-06-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ji Jiang , Heather Finlay , Soong-Hoon Kim , Wei Meng , George O. Tora
IPC: C07D401/12 , C07D221/00 , C07D401/14 , C07D471/04 , C07D413/14
Abstract: The present invention provides compounds of Formula (I) wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US10392347B2
公开(公告)日：2019-08-27
申请号：US15767364
申请日：2016-10-13
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Soong-Hoon Kim , Hannguang J. Chao , Heather Finlay , Ji Jiang , James A. Johnson , R. Michael Lawrence , Michael C. Myers , Monique Phillips , George O. Tora , Wei Meng
IPC: C07D213/82 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/107 , C07D498/10 , C07D401/12 , C07D471/10
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20180297954A1
公开(公告)日：2018-10-18
申请号：US15767364
申请日：2016-10-13
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Soong-Hoon Kim , Hannguang J. Chao , Heather Finlay , Ji Jang , James A. Johnson , R. Michael Lawrence , Michael C. Myers , Monique Phillips , George O. Tora , Wei Meng
IPC: C07D213/82 , C07D401/12 , C07D401/14 , C07D413/14 , C07D401/06 , C07D405/14 , C07D417/14 , C07D417/12 , C07D498/10 , C07D413/12 , C07D491/107 , C07D471/10
CPC classification number: C07D213/82 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/10 , C07D491/107 , C07D498/10
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, O and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20140235673A1
公开(公告)日：2014-08-21
申请号：US14347662
申请日：2012-09-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , John Llyod , Jennifer X. Qiao , Tammy C. Wang , George O. Tora
IPC: C07D213/81 , C07D413/04 , C07D401/12 , C07D213/89 , C07D401/04 , C07D409/04
CPC classification number: C07D213/81 , C07D213/34 , C07D213/89 , C07D401/04 , C07D401/12 , C07D409/04 , C07D413/04
Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
Abstract translation: 本发明提供了如说明书中所定义的式（I）化合物和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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公开(公告)号：US20220356179A1
公开(公告)日：2022-11-10
申请号：US17349980
申请日：2021-06-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Peter W. Glunz , Vladimir Ladziata , Indawati De Lucca , George O. Tora , Tarun Kumar Maishal , Raghuram Tangirala , Kamalraj Thiyagarajan
IPC: C07D417/12 , C07D401/14 , C07D403/12 , C07D417/14 , C07D471/04 , C07D491/052 , C07D495/04 , C07D519/00
Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
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Patent Agency Ranking
公开(公告)号：US20210147406A1
公开(公告)日：2021-05-20
申请号：US16629717
申请日：2018-07-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Peter W. Glunz , Vladimir Ladziata , Indawati De Lucca , George O. Tora , Tarun Kumar Maishal , Raghuram Tangirala , Kamalraj Thiyagarajan
IPC: C07D417/12 , C07D471/04 , C07D519/00 , C07D495/04 , C07D491/052 , C07D403/12 , C07D401/14 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
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公开(公告)号：US20190002441A1
公开(公告)日：2019-01-03
申请号：US16122975
申请日：2018-09-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang
IPC: C07D403/06 , C07D403/02 , C07D417/14 , A61K31/505 , C07D239/557 , C07D401/14 , C07D401/06 , C07D471/04 , C07D239/54 , C07D239/545 , C07D403/14
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US10106528B2
公开(公告)日：2018-10-23
申请号：US15468230
申请日：2017-03-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang
IPC: C07D403/06 , A61K31/505 , C07D239/54 , C07D239/545 , C07D401/14 , C07D403/02 , C07D417/14 , C07D471/04 , C07D401/06 , C07D403/14 , C07D239/557
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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9.发明授权公开(公告)号：US09493412B2
公开(公告)日：2016-11-15
申请号：US14346751
申请日：2012-09-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jennifer X. Qiao , Heather Finlay , Ji Jiang , John Lloyd , Carol Hui Hu , Zulan Pi , George O. Tora , James Neels , Jon J. Hangeland , Todd J. Friends
IPC: C07D207/38 , C07D409/12 , C07D471/04 , C07D401/12 , C07D413/12 , C07D417/12 , C07D403/12 , C07D401/04 , C07D405/12 , C07F7/08
CPC classification number: C07D207/38 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07F7/0812
Abstract: The present invention provides compounds of Formula (I): (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
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公开(公告)号：US20150239879A1
公开(公告)日：2015-08-27
申请号：US14427105
申请日：2013-09-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： George O. Tora , Heather Finlay , Carol Hui Hu , Ji Jiang , James A. Johnson , Soong-Hoon Kim , John Lloyd , Brandon Parkhurst , Zulan Pi , Jennifer X. Qiao , Tammy C. Wang
IPC: C07D417/06 , C07D417/14
CPC classification number: C07D417/06 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicament.
Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。
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