Invention Grant
- Patent Title: Oncolytic viruses for sensitizing tumor cells to killing by natural killer cells
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Application No.: US16616671Application Date: 2018-05-25
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Publication No.: US11684637B2Publication Date: 2023-06-27
- Inventor: Griffith Parks , Alicja Copik
- Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
- Applicant Address: US FL Orlando
- Assignee: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
- Current Assignee: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
- Current Assignee Address: US FL Orlando
- Agency: Meunier Carlin & Curfman LLC
- International Application: PCT/US2018/034655 2018.05.25
- International Announcement: WO2018/218151A 2018.11.29
- Date entered country: 2019-11-25
- Main IPC: A61K35/76
- IPC: A61K35/76 ; A61K35/768 ; C07K14/705 ; C12N7/00 ; A61K35/17 ; C07K16/00
Abstract:
Disclosed are engineered oncolytic viruses, related fusion proteins and polynucleotides encoding them, and methods for treating cancer using the engineered viruses. In one aspect, disclosed herein are engineered oncolytic viruses, wherein the oncolytic virus expresses one or more exogenous membrane bound immune cell targeting ligands comprising an uncleaved signal anchor.
Public/Granted literature
- US20210145876A1 NOVEL ONCOLYTIC VIRUSES FOR SENSITIZING TUMOR CELLS TO KILLING BY NATURAL KILLER CELLS Public/Granted day:2021-05-20
Information query
