公开(公告)号：US20240000842A1

公开(公告)日：2024-01-04

申请号：US18317616

申请日：2023-05-15

Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Griffith Parks ,  Alicja Copik

IPC: A61K35/17 ,  A61K35/768 ,  C07K14/705 ,  C07K16/00 ,  C12N7/00

CPC classification number: A61K35/17 ,  A61K35/768 ,  C07K14/705 ,  C07K16/00 ,  C12N7/00 ,  C12N2760/18721 ,  C12N2760/18732 ,  C12N2760/18745

Abstract: Disclosed are engineered oncolytic viruses, related fusion proteins and polynucleotides encoding them, and methods for treating cancer using the engineered viruses.

公开(公告)号：US11684637B2

公开(公告)日：2023-06-27

申请号：US16616671

申请日：2018-05-25

Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Griffith Parks ,  Alicja Copik

IPC: A61K35/76 ,  A61K35/768 ,  C07K14/705 ,  C12N7/00 ,  A61K35/17 ,  C07K16/00

CPC classification number: A61K35/17 ,  A61K35/768 ,  C07K14/705 ,  C07K16/00 ,  C12N7/00 ,  C12N2760/18721 ,  C12N2760/18732 ,  C12N2760/18745

Abstract: Disclosed are engineered oncolytic viruses, related fusion proteins and polynucleotides encoding them, and methods for treating cancer using the engineered viruses. In one aspect, disclosed herein are engineered oncolytic viruses, wherein the oncolytic virus expresses one or more exogenous membrane bound immune cell targeting ligands comprising an uncleaved signal anchor.

公开(公告)号：US20210145876A1

公开(公告)日：2021-05-20

申请号：US16616671

申请日：2018-05-25

Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Griffith Parks ,  Alicja Copik

IPC: A61K35/17 ,  C12N7/00 ,  C07K16/00 ,  C07K14/705 ,  A61K35/768

Abstract: Disclosed are engineered oncolytic viruses, related fusion proteins and polynucleotides encoding them, and methods for treating cancer using the engineered viruses. In one aspect, disclosed herein are engineered oncolytic viruses, wherein the oncolytic virus expresses one or more exogenous membrane bound immune cell targeting ligands comprising an uncleaved signal anchor.

公开(公告)号：US20200237822A1

公开(公告)日：2020-07-30

申请号：US16752040

申请日：2020-01-24

Applicant: University of Central Florida Research Foundation, Inc.

Inventor： Alicja Copik ,  Griffith Parks ,  Jeremiah Oyer

IPC: A61K35/17 ,  C07K14/735 ,  C07K14/115 ,  C07K14/54 ,  A61P35/04

Abstract: Compositions and methods for stimulating NK cell expansion and cytotoxicity are described. Therapeutic compositions and methods using expanded and stimulated NK cells are described.