- 专利标题： Systems, methods, and compositions for targeted nucleic acid editing
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申请号： US15930478申请日： 2020-05-13
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公开(公告)号： US11685916B2公开(公告)日： 2023-06-27
- 发明人: Feng Zhang , Jonathan Gootenberg , David Benjamin Turitz Cox , Omar Abudayyeh , Soumya Kannan
- 申请人： THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- 申请人地址： US MA Cambridge
- 专利权人： THE BROAD INSTITUTE, INC.,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- 当前专利权人： THE BROAD INSTITUTE, INC.,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- 当前专利权人地址： US MA Cambridge; US MA Cambridge; US MA Cambridge
- 代理机构： Johnson, Marcou, Isaacs & Nix, LLC
- 代理商 F. Brent Nix, Esq.
- 主分类号： C12N15/10
- IPC分类号： C12N15/10 ; C12N9/22 ; A61K38/00 ; C12N9/78 ; C12N9/12 ; C07K14/295
摘要：
The disclosure provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.
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