公开(公告)号：US20240299524A1

公开(公告)日：2024-09-12

申请号：US18594291

申请日：2024-03-04

申请人： SANOFI

发明人： Nadège ARNAUD BARBE ,  Leah COLE ,  Andreas KARLSSON ,  Violette SANCHEZ ,  Timothy TIBBITTS

IPC分类号： A61K39/118 ,  A61K39/00 ,  A61P31/04 ,  C07K14/295

CPC分类号： A61K39/118 ,  A61P31/04 ,  C07K14/295 ,  A61K2039/53 ,  A61K2039/70 ,  C12N2760/16134

摘要： This invention relates to compositions (e.g., vaccine compositions) which can be used to immunise against Chlamydia infections. The compositions comprise Chlamydia sp. antigens and antigen combinations which can be used to immunise against Chlamydia sp., used in the form of nucleic acids (e.g., mRNAs) encoding antigenic proteins or in the form of recombinant protein antigens.

公开(公告)号：US20230235339A1

公开(公告)日：2023-07-27

申请号：US17881471

申请日：2022-08-04

申请人： The Scripps Research Institute

发明人： Floyd E. ROMESBERG ,  Denis A. MALYSHEV

IPC分类号： C12N15/70 ,  C12P19/34 ,  C12N15/82 ,  C07K14/295 ,  C07K14/405

CPC分类号： C12N15/70 ,  C12P19/34 ,  C12N15/8243 ,  C07K14/295 ,  C07K14/405

摘要： A recombinantly expressed nucleotide triphosphate transporter efficiently imports the triphosphates of unnatural nucleotides into cells, and the endogenous cellular machinery incorporates those nucleotides into cellular nucleic acids. UBPs can therefore form within the cell's nucleic acids. Moreover, neither the presence of the unnatural triphosphates nor the replication of the UBP represents a significant growth burden. The UBP is not efficiently excised by nucleic acid repair pathways, and therefore can be retained as long as the unnatural triphosphates are available in the growth medium. Thus, the resulting cell is the first organism to stably propagate an expanded genetic alphabet.

公开(公告)号：US11406695B2

公开(公告)日：2022-08-09

申请号：US16894968

申请日：2020-06-08

申请人： Merck Sharp & Dohme LLC

发明人： Lan Zhang ,  Zhiyun Wen ,  Craig T. Przysiecki ,  Ping Qiu

IPC分类号： C07H21/02 ,  C07H19/00 ,  C07H21/00 ,  A61K39/118 ,  A61K39/02 ,  C07K14/295 ,  A61P31/04 ,  C12N15/70 ,  A61K39/00

摘要： The present invention relates to methods for the recombinant expression of chlamydia major outer membrane protein (MOMP) comprising transforming a population of E. coli host cells with an expression vector comprising a nucleic acid molecule that encodes chlamydia MOMP and encodes a leader sequence for targeting the MOMP to the outer membrane of the cell, wherein the nucleic acid molecule is operatively linked to a promoter. The method of the invention allows expression of MOMP in the outer membrane of the cell, which leads to protein folding that is more like native MOMP relative to a MOMP protein that is expressed intracellularly. Also provided by the invention are uses of the recombinant MOMP in pharmaceutical compositions and methods for the treatment and/or prophylaxis of chlamydia infection and/or the effects thereof.

公开(公告)号：US20210205433A1

公开(公告)日：2021-07-08

申请号：US17155264

申请日：2021-01-22

申请人： Statens Serum Institut

发明人： Frank Follmann ,  Ida Rosenkrands ,  Anja Olsen ,  Peter Andersen

IPC分类号： A61K39/118 ,  C07K14/295

摘要： The present invention describes an efficient vaccine against a Chlamydia trachomatis (Ct). The vaccine is based on recombinant fusion molecules that are capable of generating a high titered neutralizing antibody response that is protective against various Ct serovars. Our invention furthermore describe the combination of these antibody promoting fragments with Ct antigens that are targets for T cells with the aim to provide a vaccine that activate both arms of the immune system.

公开(公告)号：US10393742B2

公开(公告)日：2019-08-27

申请号：US15560582

申请日：2016-03-22

申请人： Universiteit Gent

发明人： Daisy Vanrompay

IPC分类号： A61K39/00 ,  A61K39/118 ,  C12Q1/00 ,  G01N33/569 ,  C07K7/06 ,  C07K7/08 ,  C07K14/295 ,  C07K17/00

摘要： The present invention relates to a method for detecting and diagnosing Chlamydia suis infections in a subject, and a diagnostic kit therefor.

公开(公告)号：US09920314B2

公开(公告)日：2018-03-20

申请号：US14705815

申请日：2015-05-06

申请人： President and Fellows of Harvard College

发明人： Darren E. Higgins ,  Michael N. Starnbach ,  Todd Gierahn ,  Nadia R. Roan

IPC分类号： A61K39/00 ,  C07K14/295 ,  C12N15/10 ,  G01N33/50 ,  C12Q1/70 ,  C12Q1/68 ,  A61K38/00

CPC分类号： C12N15/1037 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  C07K14/295 ,  C07K2319/00 ,  C12N15/1034 ,  C12N15/1072 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/5047

摘要： Replicable libraries having discrete members in defined locations for screening for antigens to a pathogenic organism are provided. Also provided are methods for using such libraries as well as a specific antigen, CT788, which induces T-cell activation during a Chlamydia infection.

公开(公告)号：US20110110857A1

公开(公告)日：2011-05-12

申请号：US12921271

申请日：2009-03-06

申请人： Roberto Petracca ,  Renata Maria Grifantini ,  Guido Grandi

发明人： Roberto Petracca ,  Renata Maria Grifantini ,  Guido Grandi

IPC分类号： A61K49/00 ,  C07K14/295 ,  C12N9/48 ,  C07K16/12 ,  C07H21/04 ,  C12N15/70 ,  C12N1/21 ,  A61K39/40 ,  G01N33/53 ,  A61P31/04

CPC分类号： A61K39/118 ,  A61K39/00 ,  A61K2039/55544 ,  A61K2039/55561 ,  C07K14/295 ,  C07K16/125 ,  C07K2317/76 ,  G01N2333/295

摘要： An immunogenic Chlamydia HtrA protein, which has one or more mutations relative to wild-type Chlamydia HtrA that result in a reduced or eliminated protease activity relative to the protease activity of wild-type Chlamydia HtrA. In some embodiments the serine protease activity is reduced or eliminated.

摘要翻译： 免疫原性衣原体HtrA蛋白，其相对于野生型衣原体HtrA具有一个或多个相对于野生型衣原体HtrA的蛋白酶活性降低或消除的蛋白酶活性的一个或多个突变。 在一些实施方案中，丝氨酸蛋白酶活性被降低或消除。

公开(公告)号：US07736873B2

公开(公告)日：2010-06-15

申请号：US11932276

申请日：2007-10-31

申请人： Andrew D. Murdin ,  Raymond P. Oomen ,  Joe Wang ,  Pamela Dunn

发明人： Andrew D. Murdin ,  Raymond P. Oomen ,  Joe Wang ,  Pamela Dunn

IPC分类号： C12P21/04 ,  A61K39/118 ,  C07K14/195 ,  C07K14/295 ,  C12P21/06

CPC分类号： A61K39/118 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K14/295 ,  C07K2319/01 ,  C07K2319/02 ,  E02D3/02 ,  Y10S530/811 ,  Y10S530/814 ,  Y10S530/82

摘要： The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector containing a nucleotide sequence encoding a 98 kDa outer membrane protein of a strain of Chlamydia pneumoniae and a promoter to effect expression of the 98 kDa outer membrane protein gene in the host. Modifications are possible within the scope of this invention.

摘要翻译： 本发明提供了一种核酸的方法，包括DNA，宿主（包括人）免疫针对由衣原体特异性肺炎衣原体感染引起的疾病，使用含有编码98kDa外膜的核苷酸序列的载体 肺炎衣原体菌株的蛋白质和在宿主中表达98kDa外膜蛋白基因的启动子。 在本发明的范围内可以进行修改。

公开(公告)号：US07534445B2

公开(公告)日：2009-05-19

申请号：US10766711

申请日：2004-01-27

申请人： W. James Jackson ,  John L. Pace

发明人： W. James Jackson ,  John L. Pace

IPC分类号： A61K39/118 ,  C07K14/295 ,  C12P21/04 ,  C07H21/04

CPC分类号： G01N33/56927 ,  A61K38/00 ,  A61K39/00 ,  C07K14/295 ,  C07K16/125 ,  G01N2333/295 ,  Y10S514/885 ,  Y10S514/931 ,  Y10S514/937 ,  Y10S530/811 ,  Y10S530/814 ,  Y10S530/82

摘要： A high molecular weight (“HMW”) protein of chlamydia, the amino acid sequence thereof, and antibodies that specifically bind the HMW protein are disclosed as well as the nucleic acid sequence encoding the same. Also disclosed are prophylactic and therapeutic compositions, comprising the HMW protein, a fragment thereof, or an antibody that specifically binds the HMW protein or a portion thereof, or the nucleotide sequence encoding the HMW protein or a fragment thereof, including vaccines.

摘要翻译： 公开了衣原体的高分子量（“HMW”）蛋白，其氨基酸序列和与HMW蛋白特异性结合的抗体，以及编码该HMW蛋白的核酸序列。 还公开了包含HMW蛋白，其片段或特异性结合HMW蛋白或其部分的抗体或编码HMW蛋白或其片段（包括疫苗）的核苷酸序列的预防和治疗组合物。

公开(公告)号：US20080166376A1

公开(公告)日：2008-07-10

申请号：US10580142

申请日：2004-11-19

申请人： Robert Brunham ,  Scott Gallichan ,  Andrew Murdin ,  Ausra Raudonikiene

发明人： Robert Brunham ,  Scott Gallichan ,  Andrew Murdin ,  Ausra Raudonikiene

IPC分类号： A61K39/118 ,  C07H21/04 ,  A61K31/711 ,  C12N1/00 ,  C07K14/295 ,  C12P21/06 ,  C07K16/12 ,  A61K38/16

CPC分类号： A61K39/118 ,  A61K39/00 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/55577 ,  C07K14/295

摘要： The present invention provides nucleic acids, proteins and vectors for a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. trachomatis. The method employs a vector containing a nucleotide sequence encoding a Mgp002 polypeptide of a strain of Chlamydia operably linked to a promoter to effect expression of the gene product in the host. Truncated forms of the full-length Mgp002 gene are useful immunogens for protecting against disease caused by infection with Chlamydia. The invention further provides recombinant Mgp002 protein useful for protecting against disease caused by infection with Chlamydia.

摘要翻译： 本发明提供了核酸的核酸，蛋白质和载体，包括DNA，宿主（包括人）免疫针对由衣原体菌株，特别是沙眼衣原体感染引起的疾病。 该方法使用含有编码与启动子可操作连接的衣原体菌株的Mgp002多肽的核苷酸序列的载体，以在宿主中表达基因产物。 全长Mgp002基因的截短形式是用于防止由衣原体感染引起的疾病的有用的免疫原。 本发明还提供了可用于防止由衣原体感染引起的疾病的重组Mgp002蛋白。