- 专利标题: Targeted drug delivery through affinity based linkers
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申请号: US16736495申请日: 2020-01-07
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公开(公告)号: US11701429B2公开(公告)日: 2023-07-18
- 发明人: Shiladitya Sengupta , Monideepa Roy , Nimish Gupta , Seikh Samad Hossain
- 申请人: AKAMARA THERAPEUTICS, INC.
- 申请人地址: US PA Philadelphia
- 专利权人: AKAMARA THERAPEUTICS, INC.
- 当前专利权人: AKAMARA THERAPEUTICS, INC.
- 当前专利权人地址: US PA Philadelphia
- 代理机构: Nixon Peabody LLP
- 代理商 David S. Resnick; Ravinderjit S. Braich
- 优先权: IN 732DEL2014 2014.03.12
- 分案原申请号: US15124058
- 主分类号: A61K39/00
- IPC分类号: A61K39/00 ; A61K47/68 ; C07K16/28 ; C07K16/32
摘要:
The current invention describes a conjugate of a targeting moiety linked to a drug via a molecule having high affinity for the targeting moiety at physiological pH such that the drug releases at low pH from the targeting moiety.
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