公开(公告)号：US11701429B2

公开(公告)日：2023-07-18

申请号：US16736495

申请日：2020-01-07

申请人： AKAMARA THERAPEUTICS, INC.

发明人： Shiladitya Sengupta ,  Monideepa Roy ,  Nimish Gupta ,  Seikh Samad Hossain

IPC分类号： A61K39/00 ,  A61K47/68 ,  C07K16/28 ,  C07K16/32

CPC分类号： A61K47/6851 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6889 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/52 ,  C07K2317/73

摘要： The current invention describes a conjugate of a targeting moiety linked to a drug via a molecule having high affinity for the targeting moiety at physiological pH such that the drug releases at low pH from the targeting moiety.

公开(公告)号：US10533059B2

公开(公告)日：2020-01-14

申请号：US15124058

申请日：2015-03-11

申请人： AKAMARA THERAPEUTICS, INC.

发明人： Shiladitya Sengupta ,  Monideepa Roy ,  Nimish Gupta ,  Seikh Samad Hossain

IPC分类号： A61K39/00 ,  C07K16/00 ,  C07K16/32 ,  C07K16/28 ,  A61K47/68

摘要： The current invention discloses targeted drug delivery conjugates comprising a targeting moiety linked to a drug via a molecule having an affinity for the targeting moiety. Typically, the conjugate comprises a targeting ligand and a molecule of interest, e.g., a therapeutic agent. The targeting ligand and the molecule of interest are linked to each other via an affinity ligand. The affinity ligand is further covalently or non-covalently linked to a drug or therapeutic agent. The drug can be modified to make it more soluble and so that it cleaves from the linking molecule at the target site.