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公开(公告)号：US10730899B2
公开(公告)日：2020-08-04
申请号：US16123430
申请日：2018-09-06
发明人： Shiladitya Sengupta , Monideepa Roy , Arindam Sarkar , SK Samad Hossain , Aniruddha Sengupta , Pradip Dutta , Aasif Ansari
摘要： The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to platinum based compounds comprising platinum moiety, linker moiety and lipid moiety and corresponding nanoparticles thereof. The disclosure further relates to synthesis of said platinum based compounds, nanoparticles and compositions comprising said platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by employing aforesaid carbene compounds, platinum based compounds, nanoparticles and compositions thereof.
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公开(公告)号：US10800801B2
公开(公告)日：2020-10-13
申请号：US16302352
申请日：2017-05-18
发明人： Sarkar Arindam , Gavin Pringle , Jonathan Loughrey , Saurabh Chitre , Hayley Reece , Attilia Figini , Ivan Ruggiero
摘要： The present disclosure relates to pharmaceutical sciences and chemical sciences. In particular, the present disclosure provides crystalline platinum-based compound IO-125, compositions and formulations comprising the same, along with method of preparing said crystalline compound, and uses thereof.
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公开(公告)号：US20240342128A1
公开(公告)日：2024-10-17
申请号：US18751933
申请日：2024-06-24
IPC分类号： A61K31/282 , A61K9/00 , A61K31/575 , A61K33/243 , A61P35/04 , C07F15/00 , C07H23/00 , C07J41/00 , C07J51/00
CPC分类号： A61K31/282 , A61K9/0019 , A61K31/575 , A61K33/243 , A61P35/04 , C07F15/0006 , C07H23/00 , C07J41/00 , C07J41/0055 , C07J51/00
摘要： The present invention pertains to a method of treating cancer or its relapse in mammals by employing platinum based compounds. More particularly, the present invention provides to enhance immunity in a mammal, using a compound of Formula I and/or Formula II, preferably Compound 1 or its derivative, salt, tautomeric form, isomer, polymorph, solvate, or intermediates thereof. The method of inducing an immune response in a mammal is mediated through immune memory. The present invention also provides for such platinum based compounds and their use in treating cancer, metastasis or cancer relapse.
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公开(公告)号：US20210275677A1
公开(公告)日：2021-09-09
申请号：US17258610
申请日：2019-07-10
摘要： The present disclosure provides methods for treating cancer in amount of a compound of formula (VIII), or a pharmaceutically acceptable salt thereof, wherein Q, linker, and lipid are defined herein, and (ii) a therapeutically effective amount of an immune checkpoint inhibitor. Q-linker-lipid (VIII) In some embodiments, the compound is the following structure (IO-125), or a pharmaceutically acceptable salt thereof; Pharmaceutical compositions comprising a compound of formula (VIII), such as IO-125, or a pharmaceutically acceptable salt thereof, an immune checkpoint inhibitor, and a pharmaceutically acceptable excipient are also described.
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公开(公告)号：US10533059B2
公开(公告)日：2020-01-14
申请号：US15124058
申请日：2015-03-11
摘要： The current invention discloses targeted drug delivery conjugates comprising a targeting moiety linked to a drug via a molecule having an affinity for the targeting moiety. Typically, the conjugate comprises a targeting ligand and a molecule of interest, e.g., a therapeutic agent. The targeting ligand and the molecule of interest are linked to each other via an affinity ligand. The affinity ligand is further covalently or non-covalently linked to a drug or therapeutic agent. The drug can be modified to make it more soluble and so that it cleaves from the linking molecule at the target site.
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公开(公告)号：US20190231894A1
公开(公告)日：2019-08-01
申请号：US16311484
申请日：2017-07-05
IPC分类号： A61K47/68 , A61P35/00 , G16B15/30 , A61K31/337
CPC分类号： A61K47/6803 , A61K31/337 , A61K47/60 , A61P35/00 , G16B15/00 , G16B15/20 , G16B15/30 , G16B40/00 , G16C10/00 , G16C20/50
摘要： The disclosure provides a process of designing and optimizing supramolecular therapeutics. The disclosure also provides a method for designing and optimizing antibody drug conjugates.
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公开(公告)号：US11701429B2
公开(公告)日：2023-07-18
申请号：US16736495
申请日：2020-01-07
CPC分类号： A61K47/6851 , A61K47/6803 , A61K47/6849 , A61K47/6889 , C07K16/2863 , C07K16/32 , C07K2317/52 , C07K2317/73
摘要： The current invention describes a conjugate of a targeting moiety linked to a drug via a molecule having high affinity for the targeting moiety at physiological pH such that the drug releases at low pH from the targeting moiety.
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公开(公告)号：US11554175B2
公开(公告)日：2023-01-17
申请号：US16311484
申请日：2017-07-05
IPC分类号： A61K47/68 , A61P35/00 , A61K47/60 , G16B40/00 , G16C20/50 , G16B15/30 , A61K31/337 , G16B15/00 , G16C10/00 , G16B15/20
摘要： The disclosure provides a process of designing and optimizing supramolecular therapeutics. The disclosure also provides a method for designing and optimizing antibody drug conjugates.
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公开(公告)号：US11358978B2
公开(公告)日：2022-06-14
申请号：US15575090
申请日：2016-05-18
发明人： Nimish Gupta , Arindam Sarkar , Heeralal Bassi , Pradip Dutta
摘要： The present invention is in relation to the fields of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to improved methods for preparing lipid-conjugated platinum compounds with high purity and good yields. The present disclosure also relates to nanoparticles comprising lipid-conjugated platinum compounds with high drug loading efficiency for use in chemotherapy, and to methods for producing said nanoparticles.
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公开(公告)号：US20220168261A1
公开(公告)日：2022-06-02
申请号：US17430849
申请日：2020-02-14
发明人： Heena AGGARWAL , Shweta CHAUBEY , Rajat DESIKAN , Nimish GUPTA , Sonia JAIN , Seema MITTAL , Shiladitya SENGUPTA
IPC分类号： A61K31/282 , A61P35/00
摘要： The present disclosure relates to methods of managing cancer by modulating/inhibiting cap methyltransferase enzyme. The modulation/inhibition is carried out by pharmacological or biological inhibitors, including but not limited to compounds of formula (VIII) or Compound A or A-1. Thus, the present disclosure relates to such inhibitors including compounds of formula (VIII) and their use for management of cancer. In some aspects, the compound of formula (VIII) is Compound 1. The present disclosure also relates to methods of activating B cells or T cells via modulation of cap methyltransferases. The present disclosure also relates to methods of managing cancer with a molecule or biologic that generates unmethylated RNA. The generation of unmethylated RNA activates B cells and presents the RNA to B-cell receptor (BCR). The present disclosure therefore also relates to management of cancer by activating B cells and then adoptively transferring the B cells to exert an anticancer effect.
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