- 专利标题： Fusion protein comprising a blood-brain barrier (BBB)-crossing single domain antibody Fc5, an immunoglobulin Fc fragment and a beta-amyloid binding polypeptide (ABP)
-
申请号： US16481898申请日： 2018-01-30
-
公开(公告)号： US11702466B2公开(公告)日： 2023-07-18
- 发明人: Balu Chakravarthy , Danica Stanimirovic , Yves Durocher
- 申请人： National Research Council of Canada
- 申请人地址： CA Ottawa
- 专利权人： National Research Council of Canada
- 当前专利权人： National Research Council of Canada
- 当前专利权人地址： CA Ottawa
- 代理机构： Cooley LLP
- 国际申请： PCT/IB2018/050576 2018.01.30
- 国际公布： WO2018/138709A 2018.08.02
- 进入国家日期： 2019-07-30
- 主分类号： C07K16/46
- IPC分类号： C07K16/46 ; C07K16/00 ; C07K14/00 ; A61K39/00 ; A61K38/00 ; C07K16/18 ; A61K9/00 ; C07K14/47
摘要：
A brain-penetrating composition of amyloid-ß binding peptide is disclosed. This may be useful in the treatment of Alzheimer's disease, for example as a bifunctional molecule, comprising a blood-brain barrier crossing antibody and an amyloid-ß targeting peptide linked via an Fc fragment that is able to transmigrate across the blood-brain barrier into the brain, and compositions comprising same. Methods of using this composition for treating Alzheimer's disease are disclosed.
公开/授权文献
信息查询
