Described herein are heating, ventilation, air conditioning, and refrigeration (HVACR) systems and methods directed to indoor air quality. HVACR systems and methods are based on dynamic people modeling to simulate and/or to monitor airflow impact on pathogen spread in an indoor space. HVACR systems and methods model an indoor space with pathogen killing technology to deploy the pathogen killing technology. HVACR systems and methods are directed to control administration of a pathogen killing technology to an indoor space based on factors that impact airflow including from dynamic analytics, a known input, and/or detection.