- 专利标题: Liquid pharmaceutical composition
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申请号: US17069118申请日: 2020-10-13
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公开(公告)号: US11712471B2公开(公告)日: 2023-08-01
- 发明人: Gianluca Rinaldi , Silvia Fratarcangeli , Alessandra Del Rio
- 申请人: Fresenius Kabi Deutschland GmbH
- 申请人地址: DE Bad Homburg
- 专利权人: Fresenius Kabi Deustschland GmbH
- 当前专利权人: Fresenius Kabi Deustschland GmbH
- 当前专利权人地址: DE Bad Homburg
- 代理机构: Goodwin Procter LLP
- 优先权: EP 169753 2014.05.23
- 主分类号: A61K6/00
- IPC分类号: A61K6/00 ; C07K1/00 ; A61K39/395 ; A61K9/00 ; A61K47/26 ; C07K16/24 ; A61K9/19 ; A61K47/02 ; A61K47/12 ; A61K39/00
摘要:
The present invention relates to novel liquid pharmaceutical compositions of adalimumab, which include adalimumab or a biosimilar thereof, an acetate buffering agent/system such as sodium acetate/acetic acid, and a sugar stabiliser such as trehalose. Such a combination of components furnishes formulations having a stability (e.g. on storage and when exposed to stress) which is comparable to or an improvement upon those known in the art, and with fewer ingredients. Such advances will help adalimumab treatments to become more widely available at lower cost, and prolong the viability of pre-loaded delivery devices (e.g. pre-filled syringes) to reduce unnecessary waste of the drug.
公开/授权文献
- US11197930B2 Liquid pharmaceutical composition 公开/授权日:2021-12-14
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