- 专利标题： Synthetic oncolytic LNP-replicon RNA and uses for cancer immunotherapy
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申请号： US16739407申请日： 2020-01-10
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公开(公告)号： US11717548B2公开(公告)日： 2023-08-08
- 发明人: Darrell J. Irvine , Karl Dane Wittrup , Ron Weiss , Yingzhong Li , Noor Momin , Yizhou Dong
- 申请人： Massachusetts Institute of Technology , Ohio State Innovation Foundation
- 申请人地址： US MA Cambridge
- 专利权人： Massachusetts Institute of Technology,Ohio State Innovation Foundation
- 当前专利权人： Massachusetts Institute of Technology,Ohio State Innovation Foundation
- 当前专利权人地址： US MA Cambridge; US OH Columbus
- 代理机构： Wolf, Greenfield & Sacks, P.C.
- 主分类号： A61K35/768
- IPC分类号： A61K35/768 ; A61P35/00 ; A61K9/00 ; C07K14/54 ; C12N7/00
摘要：
The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.
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