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公开(公告)号：US20240024394A1
公开(公告)日：2024-01-25
申请号：US18334449
申请日：2023-06-14
发明人： Darrell J. Irvine , Karl Dane Wittrup , Ron Weiss , Yingzhong Li , Noor Momin , Yizhou Dong
IPC分类号： A61K35/768 , A61P35/00 , A61K9/00 , C07K14/54 , C12N7/00
CPC分类号： A61K35/768 , A61P35/00 , A61K9/0019 , C07K14/5434 , C12N7/00 , C12N2770/36132
摘要： The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.
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公开(公告)号：US11717548B2
公开(公告)日：2023-08-08
申请号：US16739407
申请日：2020-01-10
发明人： Darrell J. Irvine , Karl Dane Wittrup , Ron Weiss , Yingzhong Li , Noor Momin , Yizhou Dong
IPC分类号： A61K35/768 , A61P35/00 , A61K9/00 , C07K14/54 , C12N7/00
CPC分类号： A61K35/768 , A61K9/0019 , A61P35/00 , C07K14/5434 , C12N7/00 , C12N2770/36132
摘要： The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.
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公开(公告)号：US20220016191A1
公开(公告)日：2022-01-20
申请号：US17320965
申请日：2021-05-14
发明人： Ron Weiss , Jin Huh , Yingzhong Li
IPC分类号： A61K35/763 , C12N15/86 , A61P35/00
摘要： Disclosed herein are genetically modified herpesviruses for the treatment of cancer. Also provided are methods of treating cancer using genetically modified herpesviruses.
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公开(公告)号：US20200281994A1
公开(公告)日：2020-09-10
申请号：US16739407
申请日：2020-01-10
发明人： Darrell J. Irvine , Karl Dane Wittrup , Ron Weiss , Yingzhong Li , Noor Momin , Yizhou Dong
IPC分类号： A61K35/768 , C12N7/00 , C07K14/54 , A61K9/00 , A61P35/00
摘要： The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.
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公开(公告)号：US20230313199A1
公开(公告)日：2023-10-05
申请号：US18023792
申请日：2021-08-31
发明人： Jianzhu Chen , Nikola Ivica , Yingzhong Li , Ting Dong
IPC分类号： C12N15/113 , G01N33/50 , A61P3/00
CPC分类号： C12N15/1138 , G01N33/5008 , A61P3/00 , C12N2310/20
摘要： Disclosed are methods of increasing mitochondrial respiration to treat obesity-related diseases and conditions, such as atherosclerosis, hypertension, diabetes, especially type 2 diabetes (NIDDM (non-insulin dependent diabetes mellitus)), impaired glucose tolerance, dyslipidemia, coronary heart disease, gallbladder disease, osteoarthritis and various types of cancer, such as endometrial, breast, prostate and colon cancers and the risk for premature death as well as other conditions, such as diseases and disorders, which conditions are improved by an increase in mitochondrial respiration. Also disclosed are methods of promoting weight gain, which is achieved by a decrease in mitochondrial respiration. Also disclosed are methods of identifying compounds useful for increasing mitochondrial respiration to treat obesity-related diseases and conditions.
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公开(公告)号：US20210324414A1
公开(公告)日：2021-10-21
申请号：US17232676
申请日：2021-04-16
发明人： Ron Weiss , Jin Huh , Yingzhong Li , Eric Goldstein , Hava Siegelmann
IPC分类号： C12N15/86 , C07K16/10 , C12N15/113 , C12N15/11 , C12N9/22 , A61K9/51 , A61K35/28 , A61P31/14 , C12N15/10
摘要： This disclosure provides engineered genetic systems for sequestering and/or destroying viruses, compositions and cells comprising the genetic systems, and methods of treating viral infections, reducing viral load, and/or reducing viral spread. The disclosure also provides libraries comprising elements to be incorporated into the engineered genetic systems.
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7.发明申请公开(公告)号：US20210324413A1
公开(公告)日：2021-10-21
申请号：US17231588
申请日：2021-04-15
发明人： Darrell J. Irvine , Ron Weiss , Yingzhong Li , Jan Lonzaric , Parisa Yousefpour
IPC分类号： C12N15/86 , A61K31/713 , A61K31/505
摘要： Genetic circuits have been developed to regulate behaviors of replicon RNA in responses to small molecules, which has broader applications, such as for quantitative expression of cargo genes, temporary expression of immunomodulatory cytokines or antigens for better cancer immunotherapy or vaccination, and for increased safety in use of self-replicating vectors or in combination with other viral-delivery vectors. Described herein are genetic circuits suitable for systems that either require a tight off state or a slow off state, which can serve for instance where either a kill switch or prolonged protein expression (e.g., of vaccine antigens) are needed.
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公开(公告)号：US20200224174A1
公开(公告)日：2020-07-16
申请号：US16739182
申请日：2020-01-10
发明人： Darrell J. Irvine , Ron Weiss , Yingzhong Li
摘要： The disclosure provides methods for an in vitro evolution technique to identify and characterize mutations in the non-structural genes of an alphavirus replicon that increase the strength and persistence of expression of the replicon genome. Also provided herein are in vivo methods for administering to an animal model a mutated alphavirus replicon that codes for a gene of experimental or therapeutic interest in the subgenome of the alphavirus replicon. The mutations identified herein improve the therapeutic potential of self-replicating RNA, which may have implications for cancer immunotherapy and beyond, e.g., for vaccination or gene therapy.
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