Disclosed Methods, Apparatus, and articles of manufacture to dynamically enable and/or disable prefetchers are disclosed. An example apparatus include an interface to access telemetry data, the telemetry data corresponding to a counter of a core in a central processing unit, the counter corresponding to a first phase of a workload executed at the central processing unit; a prefetcher state selector to select a prefetcher state for a subsequent phase based on the telemetry data; and the interface to instruct the core in the central processing unit to operate in the subsequent phase according to the prefetcher state.