Systems and methods are provided for handling sequence-dependent data as part of processing and/or analyzing large data sets in a distributed data processing environment. The distributed data processing environment can be suitable for handling data generated at a plurality of sites within a network of manufacturing sites. The systems and methods can allow for pre-processing of some values for sequence-dependent data. This can allow secondary aggregated values and/or secondary aggregated data sets to be generated from sequence-dependent data that can span multiple blocks or partitions. Pre-calculation of secondary aggregated values and/or secondary aggregated data sets for sequence-dependent data can allow the efficiencies of parallel or distributed computation to be at least partially retained while also allowing for desired processing of the sequence-dependent data.