A method for controlling deformation of a large-scale crankshaft comprising detecting and recording stress value(s) of part(s) to be regulated by the crankshaft; fixing the crankshaft on a tool to couple transmitting ends of high-energy acoustic beam transducers with the part(s) to be regulated; turning on the high-energy acoustic beam transducers to emit high-energy acoustic beams into the crankshaft, controlling working frequencies of the high-energy acoustic beam transducers within a range of 10-30 kHz, and setting a predicted regulation and control time according to the stress value(s) of the part(s) to be regulated; and closing the high-energy acoustic beam transducers when the predicted regulation and control time is reached, and taking the crankshaft out of the tool.