A power converter with over temperature protection compensation includes a main conversion unit, a primary-side control unit, a primary detection circuit, and an over temperature adjustment circuit. The primary-side control unit obtains a primary voltage change value through the primary detection circuit, and the primary-side control unit correspondingly provides a current change value to the over temperature adjustment circuit according to the primary voltage change value. The over temperature adjustment circuit provides a temperature control voltage according to the current change value so that the primary-side control unit determines whether an over temperature protection is activated according to the temperature control voltage.