![Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof](/docs/US/2023-10-10/US11780848B2/abs.jpg.600x600.jpg)
- 专利标题： Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof
-
申请号： US18176848申请日： 2023-03-01
-
公开(公告)号： US11780848B2公开(公告)日： 2023-10-10
- 发明人: Mohamed-Eslam F. Mohamed , Ahmed A. Othman , Aileen L. Pangan , In-Ho Song , Ben Klünder , Jeffrey W. Voss , Robert J. Padley , Heidi S. Camp
- 申请人： AbbVie Inc.
- 申请人地址： US IL North Chicago
- 专利权人： AbbVie Inc.
- 当前专利权人： AbbVie Inc.
- 当前专利权人地址： US IL North Chicago
- 代理机构： WOMBLE BOND DICKINSON (US) LLP
- 代理商 Danielle L. Herritt; Scott R. Breining
- 主分类号： A61K31/4985
- IPC分类号： A61K31/4985 ; C07D487/14 ; A61K9/00 ; A61K47/12 ; A61K47/38
![Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof](/abs-image/US/2023/10/10/US11780848B2/abs.jpg.150x150.jpg)
摘要：
The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and various spondyloarthritic conditions, including types of axial spondyloarthritis (axSpA)), kits, methods of synthesis, and products-by-process. In various aspects, provided are methods for treating active non-radiographic axSpA (nr-axSpA) and methods for treating active ankylosing spondylitis (AS).
公开/授权文献
信息查询
IPC分类:
