公开(公告)号：US11976077B2

公开(公告)日：2024-05-07

申请号：US18176651

申请日：2023-03-01

申请人： AbbVie Inc.

发明人： Aileen L. Pangan ,  Henrique D. Teixeira ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Ben Klünder ,  Jeffrey W. Voss ,  Robert J. Padley ,  Heidi S. Camp

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K9/20 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

CPC分类号： C07D487/14 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US11795175B2

公开(公告)日：2023-10-24

申请号：US18176647

申请日：2023-03-01

申请人： AbbVie Inc.

发明人： Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Ben Klünder ,  Aileen L. Pangan ,  Jeffrey W. Voss ,  Robert J. Padley ,  Heidi S. Camp

IPC分类号： A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07D487/14 ,  A61K9/00 ,  A61K47/02

CPC分类号： C07D487/14 ,  A61K9/0053 ,  A61K31/4985 ,  A61K47/02 ,  A61K47/38 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US11767326B2

公开(公告)日：2023-09-26

申请号：US18176653

申请日：2023-03-01

申请人： AbbVie Inc.

发明人： Aileen L. Pangan ,  Henrique D. Teixeira ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Ben Klünder ,  Jeffrey W. Voss ,  Robert J. Padley ,  Heidi S. Camp

IPC分类号： A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07D487/14 ,  A61K9/00 ,  A61K9/20

CPC分类号： C07D487/14 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3Himidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20180291029A1

公开(公告)日：2018-10-11

申请号：US15806104

申请日：2017-11-07

申请人： AbbVie Inc.

发明人： Neil WISHART ,  Maria A. Argiriadi ,  David J. Calderwood ,  Anna M. Ericsson ,  Bryan R. Fiamengo ,  Kristine E. Frank ,  Michael M. Friedman ,  Dawn M. George ,  Eric R. Goedken ,  Nathan S. Josephsohn ,  Biqin C. Li ,  Michael J. Morytko ,  Kent D. Stewart ,  Jeffrey W. Voss ,  Grier A. Wallace ,  Lu Wang ,  Kevin R. Woller

IPC分类号： C07D487/14 ,  C07D513/14 ,  C07D498/14

摘要： The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

公开(公告)号：US20240317770A1

公开(公告)日：2024-09-26

申请号：US18734105

申请日：2024-06-05

申请人： AbbVie Inc.

发明人： Ayman Allian ,  Jayanthy Jayanth ,  Mohamed-Eslam F. Mohamed ,  Mathew M. Mulhern ,  Fredrik Lars Nordstrom ,  Ahmed A. Othman ,  Michael J. Rozema ,  Lakshmi Bhagavatula ,  Patrick J. Marroum ,  Peter T. Mayer ,  Ahmad Y. Sheikh ,  Thomas B. Borchardt ,  Ben Klünder ,  Heidi S. Camp ,  Robert J. Padley ,  Jeffrey W. Voss

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/02 ,  A61K47/12 ,  A61K47/38 ,  C07D487/04

CPC分类号： C07D487/14 ,  A61K9/0053 ,  A61K31/4985 ,  A61K47/02 ,  A61K47/12 ,  A61K47/38 ,  C07D487/04 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl) pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20240166657A1

公开(公告)日：2024-05-23

申请号：US18530071

申请日：2023-12-05

申请人： AbbVie Inc.

发明人： Ayman Allian ,  Jayanthy Jayanth ,  Mohamed-Eslam F. Mohamed ,  Mathew M. Mulhern ,  Fredrik Lars Nordstrom ,  Ahmed A. Othman ,  Michael J. Rozema ,  Lakshmi Bhagavatula ,  Patrick J. Marroum ,  Peter T. Mayer ,  Ahmad Y. Sheikh ,  Thomas B. Borchardt ,  Ben Klünder ,  Heidi S. Camp ,  Robert J. Padley ,  Jeffrey W. Voss

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/02 ,  A61K47/12 ,  A61K47/38 ,  C07D487/04

CPC分类号： C07D487/14 ,  A61K9/0053 ,  A61K31/4985 ,  A61K47/02 ,  A61K47/12 ,  A61K47/38 ,  C07D487/04 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20230374027A1

公开(公告)日：2023-11-23

申请号：US18361582

申请日：2023-07-28

申请人： AbbVie Inc.

发明人： Ayman Allian ,  Jayanthy Jayanth ,  Mohamed-Eslam F. Mohamed ,  Mathew M. Mulhern ,  Fredrik Lars Nordstrom ,  Ahmed A. Othman ,  Michael J. Rozema ,  Lakshmi Bhagavatula ,  Patrick J. Marroum ,  Peter T. Mayer ,  Ahmad Y. Sheikh ,  Thomas B. Borchardt ,  Ben Klünder ,  Heidi S. Camp ,  Robert J. Padley ,  Jeffrey W. Voss

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

CPC分类号： C07D487/14 ,  A61K9/0053 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20150210708A1

公开(公告)日：2015-07-30

申请号：US14610119

申请日：2015-01-30

申请人： AbbVie Inc.

发明人： Neil Wishart ,  Maria A. Argiriadi ,  David J. Calderwood ,  Anna M. Ericsson ,  Bryan A. Fiamengo ,  Kristine E. Frank ,  Michael M. Friedman ,  Dawn M. George ,  Eric R. Goedken ,  Nathan S. Josephsohn ,  Biqin C. Li ,  Michael J. Morytko ,  Kent D. Stewart ,  Jeffrey W. Voss ,  Grier A. Wallace ,  Lu Wang ,  Kevin R. Woller

IPC分类号： C07D487/14

CPC分类号： C07D487/14 ,  C07D498/14 ,  C07D513/14

摘要： The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

摘要翻译： 本发明提供式（I）化合物的药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。

公开(公告)号：US11993605B2

公开(公告)日：2024-05-28

申请号：US18176664

申请日：2023-03-01

申请人： AbbVie Inc.

发明人： Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Ben Klünder ,  Aileen L. Pangan ,  Jaclyn Kay Anderson ,  Jeffrey W. Voss ,  Robert J. Padley ,  Heidi S. Camp

IPC分类号： A61K31/4985 ,  A61K9/00 ,  A61K47/12 ,  A61K47/38 ,  C07D487/14

CPC分类号： C07D487/14 ,  A61K9/0053 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US11780848B2

公开(公告)日：2023-10-10

申请号：US18176848

申请日：2023-03-01

申请人： AbbVie Inc.

发明人： Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Aileen L. Pangan ,  In-Ho Song ,  Ben Klünder ,  Jeffrey W. Voss ,  Robert J. Padley ,  Heidi S. Camp

IPC分类号： A61K31/4985 ,  C07D487/14 ,  A61K9/00 ,  A61K47/12 ,  A61K47/38

CPC分类号： C07D487/14 ,  A61K9/0053 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and various spondyloarthritic conditions, including types of axial spondyloarthritis (axSpA)), kits, methods of synthesis, and products-by-process. In various aspects, provided are methods for treating active non-radiographic axSpA (nr-axSpA) and methods for treating active ankylosing spondylitis (AS).