- 专利标题： Anti-HLA-A2 antibodies, related chimeric antigen receptors, and uses thereof
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申请号： US16649426申请日： 2018-09-20
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公开(公告)号： US11814432B2公开(公告)日： 2023-11-14
- 发明人: Li Zhou , Tobias Abel , François Meyer , Megan Levings , Nicolas Dawson , Caroline Lamarche
- 申请人： THE UNIVERSITY OF BRITISH COLUMBIA , SANGAMO THERAPEUTICS FRANCE
- 申请人地址： CA Vancouver
- 专利权人： The University of British Columbia,Sangamo Therapeutics France
- 当前专利权人： The University of British Columbia,Sangamo Therapeutics France
- 当前专利权人地址： CA Vancouver; FR Valbonne Sophia Antipolis
- 代理机构： Steptoe & Johnson LLP
- 代理商 Z. Ying Li; Wyan-Ching M. Lee
- 国际申请： PCT/CA2018/051174 2018.09.20
- 国际公布： WO2019/056106A 2019.03.28
- 进入国家日期： 2020-03-20
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K35/17 ; C07K14/725 ; C07K14/705 ; A61K35/12
摘要：
The present invention relates to a novel anti-HLA-A2 antibody, and to a chimeric antigen receptor comprising said HLA-A2 antibody. The present invention further relates to an immune cell expressing said chimeric receptor antigen, and to therapeutic uses thereof, in particular for treating or preventing graft rejection or GVHD.
公开/授权文献
- US20200283530A1 NOVEL ANTI-HLA-A2 ANTIBODIES AND USES THEREOF 公开/授权日：2020-09-10
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