公开(公告)号：US20230134821A1

公开(公告)日：2023-05-04

申请号：US17966227

申请日：2022-10-14

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： ARTEM TCHERKASSOV ,  PAUL S. RENNIE ,  FUQIANG BAN ,  ERIC J.J. LEBLANC ,  LAVINIA A. CARABET ,  NADA LALLOUS ,  KRITI SINGH ,  HELENE MORIN ,  ANH-TIEN TON

IPC分类号： C07C237/22 ,  C07C255/66 ,  C07C275/30 ,  C07C311/18 ,  C07C335/16 ,  C07C335/18 ,  C07D211/42 ,  C07D213/40 ,  C07D213/61 ,  C07D231/14 ,  C07D239/42 ,  C07D241/24 ,  C07D249/08 ,  C07D261/08 ,  C07D265/30 ,  C07D265/36 ,  C07D277/36 ,  C07D307/14 ,  C07D311/16 ,  C07D333/20 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/06 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04

摘要： Provided herein are Myc-Max inhibitory compounds having the structure of Formula (I) and compositions thereof for use in the treatment of cancer. In particular, the Myc-Max inhibitory compounds may be useful for the treatment of cancers selected from one or more of: prostate cancer, breast cancer, colon cancer, cervical cancer, small-cell lung carcinomas, neuroblastomas, osteosarcomas, glioblastomas, melanoma and myeloid leukaemia.

公开(公告)号：US11639348B2

公开(公告)日：2023-05-02

申请号：US16257920

申请日：2019-01-25

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： Stephen G. Withers ,  Zhizeng Gao

IPC分类号： G01N33/68 ,  C07D407/12 ,  G01N33/573 ,  G01N33/58 ,  C12Q1/34 ,  C12Q1/04

摘要： Provided herein are compounds having the structure of Formulas A-D and compositions thereof for use in the detection and quantification of viral neuraminidase. In particular, the compounds may be useful for the evaluation of viral strains and for vaccine evaluation.

公开(公告)号：US20230132202A1

公开(公告)日：2023-04-27

申请号：US17793907

申请日：2021-02-19

申请人： The University of British Columbia

发明人： Hossein YAZDANI-AHMADABADI ,  Kai YU ,  Dirk LANGE ,  Jayachandran KIZHAKKEDATHU

IPC分类号： C09D133/26 ,  C09D5/16 ,  C08L33/26 ,  C08K3/28 ,  C09D5/14

摘要： Provided herein are compositions including polymeric binder or a salt thereof, high molecular weight polymer, pharmaceutically active agent and a low molecular weight cross-linking agent, methods for using the compositions to coat a substrate, and methods for making the compositions. Alternatively, the composition may include a polymeric binder or a salt thereof, high molecular weight polymer and a pharmaceutically active agent. In particular, the substrate may form part of an apparatus on which it would be beneficial to limit biofouling and/or protein binding.

公开(公告)号：US11608353B2

公开(公告)日：2023-03-21

申请号：US16675535

申请日：2019-11-06

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： Stephen G. Withers ,  Gary D. Brayer ,  Leslie Karen Williams ,  Xiaohua Zhang

IPC分类号： A61K31/7034 ,  A61K31/7048 ,  A61K31/7032 ,  C07H15/26 ,  C07C33/26 ,  C07D311/30 ,  C07H15/203 ,  A23G4/12 ,  A23L33/105 ,  C07H1/06

摘要： There are provided compounds of Formula I: various compositions thereof and methods for their use in the inhibition of α-amylase.

公开(公告)号：US11584663B2

公开(公告)日：2023-02-21

申请号：US16851327

申请日：2020-04-17

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： Fariborz Taghipour

IPC分类号： C02F1/32 ,  C02F1/72 ,  C02F103/02

摘要： A reactor that operates with ultraviolet light emitting diodes (UV-LEDs) to attain UV photoreactions or UV photo-initiated reaction in a fluid flow for various applications, including water purification. The UV-LED reactor is comprised of a conduit means for passing fluid flow, an ultraviolet light emitting diode (UV-LED), and a radiation-focusing element to focus the UV-LED radiation to the fluid in the longitudinal direction of the conduit. The UV-LED reactor may include photocatalysts or chemical oxidants, which are activated by UV emitted by UV-LEDs for photocatalytic and photo-initiated reactions.

公开(公告)号：US20230051538A1

公开(公告)日：2023-02-16

申请号：US17283292

申请日：2019-10-07

申请人： THE UNIVERSITY OF BRITISH COLUMBIA ,  PROMIS NEUROSCIENCES, INC.

发明人： Neil R. CASHMAN ,  Steven S. PLOTKIN ,  Xubiao PENG ,  Johanne KAPLAN

IPC分类号： C07K16/18 ,  A61P25/00 ,  G01N33/68 ,  C12N15/63

摘要： The disclosure pertains to conformational epitopes in alpha-synuclein, antibodies thereto and methods of making and using immunogens and antibodies specific thereto. In particular antibodies raised to cyclic compounds comprising at least 3 amino acids of EKTKEQ (SEQ ID NO: 1) selectively recognize misfolded oligomeric alpha-synuclein and are able to inhibit alpha-synuclein propagation and toxicity.

公开(公告)号：US11566643B2

公开(公告)日：2023-01-31

申请号：US16650109

申请日：2018-09-25

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： Fariborz Taghipour

IPC分类号： C02F1/32 ,  B01J19/12 ,  F15D1/00 ,  B01J19/00 ,  B01J19/24 ,  F15D1/02 ,  F28F13/06

摘要： A fluid flow conduit according to one embodiment comprises: a body comprising a channel-defining surface which defines a principal flow channel extending in a longitudinal direction, wherein the body defines an interior flow region comprising the principal flow channel; an inlet for introducing fluid into the interior flow region, the inlet shaped so that an average velocity of fluid entering the interior flow region from the inlet is oriented in an inlet flow direction non-parallel to the longitudinal direction; and an outlet for conveying fluid out of the principal flow channel, the outlet spaced apart from the inlet in the longitudinal direction such that fluid that passes from the inlet to the outlet passes through at least a portion of the principal flow channel; wherein the fluid flow conduit defines a recess in the interior flow region and facing the inlet.

公开(公告)号：US20230010064A1

公开(公告)日：2023-01-12

申请号：US17779525

申请日：2020-09-17

申请人： The University of British Columbia

发明人： Mirza Sarwar ,  Sylvester Zhang ,  John Madden

IPC分类号： H05K1/02 ,  H05K3/00 ,  H05K1/03 ,  H05K3/18 ,  H05K1/09 ,  H05K3/46 ,  C09D11/033 ,  C09D1/00 ,  C23C18/38 ,  C23C18/16 ,  C23C28/02 ,  C25D5/56 ,  C25D3/38

摘要： A method for fabricating a circuit board comprises preparing an elastomeric substrate having a roughened surface. The elastomeric substrate is stretched before an electrically conductive material is electrolessly deposited onto the roughened surface. A suitable amount of electrically conductive material is deposited onto the elastomeric substrate before the elastomeric substrate is released from its stretch.

公开(公告)号：US11529148B2

公开(公告)日：2022-12-20

申请号：US15952093

申请日：2018-04-12

申请人： The University of British Columbia ,  British Columbia Cancer Agency Branch

发明人： Robert Meek ,  Qingan Zhu ,  Timothy Schwab ,  Robin John Noel Coope ,  Jared Slobodan ,  Scott Young

IPC分类号： A61B17/16 ,  A61B17/72

摘要： Devices for treating a bone and methods of inserting such devices into a bone are disclosed. A device for treating a bone may include a flexible tube, a stiffening mechanism and an actuator. The flexible tube has a distal end and a proximal end. The stiffening mechanism within the flexible tube is configured to cause the flexible tube to become rigid. The actuator is configured to cause the stiffening mechanism to cause the flexible tube to become rigid in response to the actuator being actuated.

公开(公告)号：US20220380785A1

公开(公告)日：2022-12-01

申请号：US17773543

申请日：2020-11-01

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： Stephen G. WITHERS ,  Lyann SIM ,  Warren William WAKARCHUK

IPC分类号： C12N15/70 ,  C12P21/00 ,  C12N9/10 ,  C12N9/90

摘要： Provided herein are enzymatic compositions for protein O-glycosylation and sialylation, methods and systems associated therewith. In particular, the composition for in vivo sialylation of therapeutic proteins. The composition comprises a polypeptide N-acetylgalactosaminyltransferase; a β-1,3-galactosyltransferase; an UDP-Glc/GlcNAc 4-epimerase; a disulfide bond isomerase; and an α-2,3-sialyltransferase or an α-2,6-sialyltransferase. Furthermore, provided herein are compositions for efficient and complete O-glycosylation and di-sialylation of therapeutic proteins.