Systems, methods, and mechanisms for performing ROHC header compression on TCP packets with MPTCP option enabled. A compressor may determine that a first portion of the stream of data packets is formatted according to the transmission control protocol (TCP) with a multipath TCP (MPTCP) option enabled. The compressor may establish context with a corresponding decompressor and may operate in one of three modes of compression based on the context. In some embodiments, when the context indicates that the corresponding decompressor supports decompression of TCP data packets with MPTCP option enabled, the compressor may operate in a first or second mode of compression. In some embodiments, when the context indicates that the corresponding decompressor does not support decompression of TCP data packets with MPTCP option enabled, the compressor may operation in a third mode of compression.