Provided are a device cross-region access method and apparatus, an electronic device, and a storage medium. The method includes: receiving a cross-region access request from a target device and determining IP address information in the cross-region access request; determining information of a cross-region proxy server matching the target device according to the IP address information, where the cross-region proxy server is preset in a proxy region different from a target region where the target server is located, and the cross-region proxy server and the target server are in a distributed deployment; and transmitting the information of the cross-region proxy server to the target device to enable the target device to establish a connection to the cross-region proxy server.