- 专利标题： Trans-indoline cyclopropylamine chemical compound, and method for preparation, pharmaceutical composition, and use thereof
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申请号： US16306751申请日： 2017-06-02
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公开(公告)号： US11873292B2公开(公告)日： 2024-01-16
- 发明人: Hong Liu , Jia Li , Wei Zhu , Yubo Zhou , Jiang Wang , Mingbo Su , Shuni Wang , Wei Xu , Chunpu Li , Weijuan Kan , Hualiang Jiang , Kaixian Chen
- 申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 申请人地址： CN Shanghai
- 专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人地址： CN Shanghai
- 代理机构： Wolf, Greenfield & Sacks, P.C.
- 优先权： CN 1610390628.6 2016.06.03
- 国际申请： PCT/CN2017/087081 2017.06.02
- 国际公布： WO2017/215464A 2017.12.21
- 进入国家日期： 2019-03-29
- 主分类号： C07D403/12
- IPC分类号： C07D403/12 ; C07D215/58 ; C07D209/04 ; C07D215/00 ; C07D487/04 ; C07D209/08 ; C07D401/12 ; C07D405/12 ; A61P35/00
摘要：
The present invention relates to the fields of medicinal chemistry and pharmacotherapy, and specifically relates to the chemical compound of formula (I), and its racemate, R-isomer, S-isomer, pharmaceutically acceptable salt, and mixtures thereof, as well as its method for preparation, a pharmaceutical composition containing said chemical compound, and use as a lysine-specific demethylase 1 (LSD 1) inhibitor. The cyclopropylamine chemical compound to which the present invention relates may be used in the treatment of cancer.
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