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公开(公告)号：US11873292B2
公开(公告)日：2024-01-16
申请号：US16306751
申请日：2017-06-02
发明人： Hong Liu , Jia Li , Wei Zhu , Yubo Zhou , Jiang Wang , Mingbo Su , Shuni Wang , Wei Xu , Chunpu Li , Weijuan Kan , Hualiang Jiang , Kaixian Chen
IPC分类号： C07D403/12 , C07D215/58 , C07D209/04 , C07D215/00 , C07D487/04 , C07D209/08 , C07D401/12 , C07D405/12 , A61P35/00
CPC分类号： C07D403/12 , A61P35/00 , C07D209/04 , C07D209/08 , C07D215/00 , C07D215/58 , C07D401/12 , C07D405/12 , C07D487/04 , Y02P20/55
摘要： The present invention relates to the fields of medicinal chemistry and pharmacotherapy, and specifically relates to the chemical compound of formula (I), and its racemate, R-isomer, S-isomer, pharmaceutically acceptable salt, and mixtures thereof, as well as its method for preparation, a pharmaceutical composition containing said chemical compound, and use as a lysine-specific demethylase 1 (LSD 1) inhibitor. The cyclopropylamine chemical compound to which the present invention relates may be used in the treatment of cancer.
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2.发明申请公开(公告)号：US20190210998A1
公开(公告)日：2019-07-11
申请号：US16306751
申请日：2017-06-02
发明人： Hong Liu , Jia Li , Wei Zhu , Yubo Zhou , Jiang Wang , Mingbo Su , Shuni Wang , Wei Xu , Chunpu Li , Weijuan Kan , Hualiang Jiang , Kaixian Chen
IPC分类号： C07D403/12 , A61P35/00 , C07D209/08 , C07D405/12 , C07D401/12 , C07D215/58
CPC分类号： C07D403/12 , A61P35/00 , C07D209/04 , C07D209/08 , C07D215/00 , C07D215/58 , C07D401/12 , C07D405/12 , Y02P20/55
摘要： The present invention relates to the fields of medicinal chemistry and pharmacotherapy, and specifically relates to the chemical compound of formula (I), and its racemate, R-isomer, S-isomer, pharmaceutically acceptable salt, and mixtures thereof, as well as its method for preparation, a pharmaceutical composition containing said chemical compound, and use as a lysine-specific demethylase 1 (LSD 1) inhibitor. The cyclopropylamine chemical compound to which the present invention relates may be used in the treatment of cancer.
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