- 专利标题： Oncolytic HSV vector
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申请号： US16985459申请日： 2020-08-05
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公开(公告)号： US11883448B2公开(公告)日： 2024-01-30
- 发明人: Hiroaki Uchida , Justus B. Cohen , Joseph C. Glorioso, III , Paola Grandi
- 申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education
- 申请人地址： US PA Pittsburgh
- 专利权人： UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- 当前专利权人： UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- 当前专利权人地址： US PA Pittsburgh
- 代理机构： Leydig, Voit & Mayer, Ltd.
- 主分类号： C12N15/00
- IPC分类号： C12N15/00 ; A61K35/763 ; C12N7/00 ; C07K14/005
摘要：
The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the surface of a cell (such as a cancer cell) and one or more copies of one or more microRNA target sequences inserted into one or more HSV gene loci, preferably one or more HSV gene(s) required for replication of HSV in normal (i.e., non-cancerous) cells. The invention further provides stocks and pharmaceutical compositions comprising the inventive oHSV and methods for killing tumor cells employing the inventive oHSV.
公开/授权文献
- US20210138007A1 ONCOLYTIC HSV VECTOR 公开/授权日：2021-05-13
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