Invention Grant
- Patent Title: Method for inducing trans-differentiation of cardiomyocytes based on exosome
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Application No.: US16456127Application Date: 2019-06-28
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Publication No.: US11884935B2Publication Date: 2024-01-30
- Inventor: Ick Chan Kwon , Sun Hwa Kim , Yoosoo Yang , Hyosuk Kim
- Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Applicant Address: KR Seoul
- Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee Address: KR Seoul
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: KR 20180074648 2018.06.28
- Main IPC: C12N5/077
- IPC: C12N5/077
Abstract:
The present invention relates to a method for inducing trans-differentiation of cardiomyocytes based on exosome, and more particularly, to a method for inducing trans-differentiation of a fibroblast into a cardiomyocyte, comprising the steps of: isolating exosomes in a culture medium during a process of differentiating a stem cell into the cardiomyocyte; culturing a fibroblast in a cardiomyocyte reprogramming medium containing the isolated exosomes; and culturing the fibroblast cultured in a cardiomyocyte differentiation medium containing the isolated exosomes.
Public/Granted literature
- US20200002677A1 METHOD FOR INDUCING TRANS-DIFFERENTIATION OF CARDIOMYOCYTES BASED ON EXOSOME Public/Granted day:2020-01-02
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