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公开(公告)号：US12006502B2
公开(公告)日：2024-06-11
申请号：US18407815
申请日：2024-01-09
发明人： HoWon J. Kim , In-San Kim , Jay S. Kim , Sun Hwa Kim , Ick Chan Kwon , Jong Won Lee , Yoo Soo Yang , Hong Yeol Yoon
IPC分类号： C12N15/113 , A61P35/00 , C12Q1/68
CPC分类号： C12N15/1138 , A61P35/00 , C12N2310/11 , C12N2310/531
摘要： Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the target cell, the therapeutic compound ultimately being internalized by the target cell via endocytosis. The target cell may be a fibrotic cell.
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公开(公告)号：US11618916B2
公开(公告)日：2023-04-04
申请号：US16568363
申请日：2019-09-12
发明人： Ick Chan Kwon , Ju Hee Ryu , Young-Ji Ko , Hye-Sun Kim , Nam-Hyuk Cho , Eun-Jeong Yang , Jae Won Lee
IPC分类号： C12Q1/37 , G01N33/573
摘要： A probe for measuring the activity of caspase-1 according to the present disclosure can specifically image cells or tissues where inflammatory response is induced because it is cleaved by reacting specifically with the active caspase-1 enzyme in vivo and in vitro and re-emits fluorescence. The probe for measuring the activity of caspase-1 can be used for various purposes, such as for imaging of cells or tissues where inflammatory response is induced, as a drug carrier, for screening of a drug inhibiting inflammatory response, etc.
The probe for measuring the activity of caspase-1 is applicable both in vivo and in vitro, and can be used for various applications such as high-throughput screening for new drug development, early diagnosis of diseases, etc.-
3.发明公开公开(公告)号：US20240360457A1
公开(公告)日：2024-10-31
申请号：US18765587
申请日：2024-07-08
发明人： HoWon J. Kim , In-San Kim , Jay S. Kim , Sun Hwa Kim , Ick Chan Kwon , Jong Won Lee , Yoo Soo Yang , Hong Yeol Yoon
IPC分类号： C12N15/113 , A61P35/00
CPC分类号： C12N15/1138 , A61P35/00 , C12N2310/11 , C12N2310/531
摘要： Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a cancer cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the cancer cell, the therapeutic compound ultimately being internalized by the cancer cell via endocytosis.
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4.发明公开公开(公告)号：US20240150771A1
公开(公告)日：2024-05-09
申请号：US18407815
申请日：2024-01-09
发明人： HoWon J. Kim , In-San Kim , Jay S. Kim , Sun Hwa Kim , Ick Chan Kwon , Jong Won Lee , Yoo Soo Yang , Hong Yeol Yoon
IPC分类号： C12N15/113 , A61P35/00
CPC分类号： C12N15/1138 , A61P35/00 , C12N2310/11 , C12N2310/531
摘要： Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the target cell, the therapeutic compound ultimately being internalized by the target cell via endocytosis. The target cell may be a fibrotic cell.
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公开(公告)号：US11246939B2
公开(公告)日：2022-02-15
申请号：US16573351
申请日：2019-09-17
发明人： Sun Hwa Kim , Ick Chan Kwon , In-San Kim , Kwangmeyung Kim , Yoosoo Yang , Young-Ji Ko
IPC分类号： A61K47/55 , A61K47/54 , A61K31/713 , C12N15/113 , C07K14/705 , A61P35/00 , A61K38/00
摘要： A fusion protein-siRNA complex according to the present disclosure binds specifically to cancer cells, is taken up effectively by the cells, and exhibits anticancer activity as it is degraded by lysosomes. The fusion protein-siRNA complex provides maximized anticancer activity so that the cancer cells can be removed by autoimmunity, by inhibiting the immunity of the cancer cells and enhancing phagocytosis by macrophages.
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公开(公告)号：US10266820B2
公开(公告)日：2019-04-23
申请号：US14754556
申请日：2015-06-29
发明人： Hyung Jun Ahn , Ick Chan Kwon , Mihue Jang , Jong Hwan Kim
IPC分类号： C12N15/11
摘要： A RNA/DNA nanoparticle for delivering siRNA where a RNA transcript including at least one hairpin structure hybridizes DNA-cholesterol conjugate and folate-DNA conjugate including a complementary sequence to the RNA transcript, and a composition including the RNA/DNA nanoparticle is provided. More specifically, because various siRNA used for different applications can be contained in the RNA/DNA nanoparticle for delivering siRNA at a high loading efficiency, and has stability to the outer attacks such as nuclease degradation. The RNA/DNA nanoparticle siRNA can be prepared by self-assembly without using polycationic agent which is harmful agent for body. The folate targeting to various cancer cells can accumulate the nanoparticle selectively on target cancer cell after intravenous injection, and make excellent gene-silencing effect inside the cancer tissue, thereby being used as a good agent for treating cancers.
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公开(公告)号：US11884935B2
公开(公告)日：2024-01-30
申请号：US16456127
申请日：2019-06-28
发明人： Ick Chan Kwon , Sun Hwa Kim , Yoosoo Yang , Hyosuk Kim
IPC分类号： C12N5/077
CPC分类号： C12N5/0657 , C12N2500/30 , C12N2500/32 , C12N2500/38 , C12N2501/235 , C12N2501/33 , C12N2506/02
摘要： The present invention relates to a method for inducing trans-differentiation of cardiomyocytes based on exosome, and more particularly, to a method for inducing trans-differentiation of a fibroblast into a cardiomyocyte, comprising the steps of: isolating exosomes in a culture medium during a process of differentiating a stem cell into the cardiomyocyte; culturing a fibroblast in a cardiomyocyte reprogramming medium containing the isolated exosomes; and culturing the fibroblast cultured in a cardiomyocyte differentiation medium containing the isolated exosomes.
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公开(公告)号：US11015197B2
公开(公告)日：2021-05-25
申请号：US16425849
申请日：2019-05-29
发明人： Sun Hwa Kim , Ick Chan Kwon , Kwangmeyung Kim , Hong Yeol Yoon , Gi-Jung Kwak , Juho Park
IPC分类号： C12N15/113 , A61P35/00
摘要： The present invention relates to a novel anti-miRNA single-stranded nucleic acid maleimide derivative, which comprises an anti-miRNA single-stranded nucleic acid having a nucleic acid sequence complementary to a nucleic acid sequence of an miRNA. Further, the present invention provides an anti-miRNA single-stranded nucleic acid-serum albumin conjugate in which serum albumin is covalently bonded to the anti-miRNA single-stranded nucleic acid maleimide derivative via the maleimide group.
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9.发明授权公开(公告)号：US09259493B2
公开(公告)日：2016-02-16
申请号：US14074865
申请日：2013-11-08
发明人： Kwang Meyung Kim , Ick Chan Kwon , Inchan Youn , Hyun Su Min , Hong Yeol Yoon , Jae Hyung Park
CPC分类号： A61K49/223 , A61K49/0032 , A61K49/0069
摘要： Disclosed is a liver tumor-targeting ultrasound contrast agent. The ultrasound contrast agent includes a gas-generating core and a hyaluronic acid shell. The ultrasound contrast agent can be specifically delivered to liver cells. This specific delivery enables easy differentiation between normal liver cells and liver tumor cells by ultrasound imaging. In addition, the ultrasound contrast agent is highly stable in aqueous condition and causes no cytotoxicity. Also disclosed is a method for preparing the ultrasound contrast agent.
摘要翻译： 公开了一种肝肿瘤靶向超声造影剂。 超声造影剂包括产气芯和透明质酸壳。 可以将超声造影剂特异性地递送至肝细胞。 这种特异性的传递使得通过超声成像容易地在正常肝细胞和肝肿瘤细胞之间分化。 此外，超声造影剂在水性条件下高度稳定，不产生细胞毒性。 还公开了一种制备超声造影剂的方法。
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10.发明授权Tumor-targeting gas-generating nanoparticle, method for preparing the same, and tumor-targeting nanoparticle for drug delivery using the same 有权肿瘤靶向产生气体的纳米颗粒，其制备方法和用于药物递送的肿瘤靶向纳米颗粒公开(公告)号：US09259395B2
公开(公告)日：2016-02-16
申请号：US13906963
申请日：2013-05-31
发明人： Ick Chan Kwon , Kwang Meyung Kim , Kuiwon Choi , Heebeom Koo , Hyun Su Min , Inchan Youn
CPC分类号： A61K9/5146 , A61K9/0004 , A61K9/0009 , A61K9/0019 , A61K9/5153 , A61K41/0028 , A61K47/6925 , A61K49/0032 , A61K49/0054 , A61K49/0093 , A61K49/222 , A61K49/225
摘要： A tumor-targeting gas-generating nanoparticle, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same relate to a tumor-targeting gas-generating nanoparticle including a polycarbonate core and a amphiphilic coat, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same. Since a tumor-targeting gas-generating nanoparticle according to the present disclosure is accumulated in the tumor tissue in large quantity and generates strong ultrasound wave signals, it can be usefully used as a contrast agent for ultrasonic imaging.
摘要翻译： 肿瘤靶向产生气体的纳米颗粒，其制备方法和使用其的药物递送的肿瘤靶向纳米颗粒涉及包含聚碳酸酯芯和两亲性涂层的肿瘤靶向产生气体的纳米颗粒，其制备方法和 用于药物递送的肿瘤靶向纳米颗粒。 由于根据本发明的肿瘤靶向产生气体的纳米颗粒大量积聚在肿瘤组织中，并且产生强大的超声波信号，因此可以有效地用作超声成像造影剂。
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