公开(公告)号：US11884935B2

公开(公告)日：2024-01-30

申请号：US16456127

申请日：2019-06-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ick Chan Kwon ,  Sun Hwa Kim ,  Yoosoo Yang ,  Hyosuk Kim

IPC: C12N5/077

CPC classification number: C12N5/0657 ,  C12N2500/30 ,  C12N2500/32 ,  C12N2500/38 ,  C12N2501/235 ,  C12N2501/33 ,  C12N2506/02

Abstract: The present invention relates to a method for inducing trans-differentiation of cardiomyocytes based on exosome, and more particularly, to a method for inducing trans-differentiation of a fibroblast into a cardiomyocyte, comprising the steps of: isolating exosomes in a culture medium during a process of differentiating a stem cell into the cardiomyocyte; culturing a fibroblast in a cardiomyocyte reprogramming medium containing the isolated exosomes; and culturing the fibroblast cultured in a cardiomyocyte differentiation medium containing the isolated exosomes.