A machine for processing individual sheets comprises at least one processing station, in particular in inkjet printing station, and a transport system (100) for transporting the individual sheets through the processing station, along a transport direction. The transport system (100) comprises at least one gripper conveyor (150) movable along the transport direction, for gripping one of the individual sheets defining a sheet position in transport direction. The transport system (100) further comprises at least one support conveyor (190) movable along the transport direction for supporting a region of the individual sheet, wherein the support conveyor (190) comprises a vacuum system for supporting the individual sheet on an interacting surface of the support conveyor, the vacuum system comprising a plurality of orifices in the interacting surface. The machine allows for efficient and flexible handling of individual sheets, in particular large format sheets of materials such as corrugated cardboard or other materials that have a certain degree of inherent stability.