Invention Grant
- Patent Title: Inhibitors of cancer invasion, attachment, and/or metastasis
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Application No.: US17148813Application Date: 2021-01-14
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Publication No.: US11891399B2Publication Date: 2024-02-06
- Inventor: Paul B. Fisher , Maurizio Pellecchia , Swadesh K. Das , Timothy P. Kegelman , Bainan Wu , Surya K. De , Jun Wei , Mitchell E. Menezes , Luni Emdad
- Applicant: VIRGINIA COMMONWEALTH UNIVERSITY , SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- Applicant Address: US VA Richmond
- Assignee: VIRGINIA COMMONWEALTH UNIVERSITY,SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- Current Assignee: VIRGINIA COMMONWEALTH UNIVERSITY,SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- Current Assignee Address: US VA Richmond; US CA La Jolla
- Agency: Goodwin Procter LLP
- The original application number of the division: US16349467
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D495/14 ; A61P35/04 ; A61K45/06 ; A61K31/519
Abstract:
Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.
Public/Granted literature
- US20210214365A1 INHIBITORS OF CANCER INVASION, ATTACHMENT, AND/OR METASTASIS Public/Granted day:2021-07-15
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