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公开(公告)号：US12272494B2
公开(公告)日：2025-04-08
申请号：US17054191
申请日：2019-05-10
Applicant: Virginia Commonwealth University
Inventor： Ahmed A. Farghaly , Maryanne M. Collinson
IPC: H01G11/30 , B01J23/42 , C22C5/04 , G01N27/30 , H01M8/1011
Abstract: A three-dimensional bicontinuous nanoporous platinum-based (3D-BC—NP—Pt(Au)) electrode is prepared by co-electrodepositing Pt and Ag to form a Pt—Ag alloy thin film on a gold substrate, annealing the Pt—Ag alloy thin film deposited on the gold substrate to produce a Pt—Ag—Au alloy, and dealloying the Pt—Ag—Au alloy by dissolving Ag to produce the nanoporous three-dimensional bicontinuous Pt—Au electrode with or without: hierarchical porosity, cylindrical nanopores, and engineered nano-cracks. Electrodes comprising Pt—Au alloys are also provided.
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2.发明申请公开(公告)号：US20250019349A1
公开(公告)日：2025-01-16
申请号：US18767363
申请日：2024-07-09
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY , IllExcor Therapeutics, LLC , KING ABDULAZIZ UNIVERSITY , CHILDREN'S HOSPITAL OF PHILADELPHIA (CHOP)
Inventor： Martin SAFO , Yan ZHANG , Andrew FLEISCHMAN , David LIGHT , Moustafa EL-ARABY , Abdelsattar OMAR , Osheiza ABDULMALIK
IPC: C07D213/30 , A61P7/06 , C07D239/26
Abstract: Compounds and methods for preventing and/or treating one or more symptoms of sickle cell diseases (SCD) by administering at least one of the compounds are provided. The compounds are chemically modified to increase bioavailability and activity, e.g., so that the compounds prevent adhesion and sickling of red blood cells (RBCs).
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公开(公告)号：US20240376332A1
公开(公告)日：2024-11-14
申请号：US18690446
申请日：2022-09-07
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Vamsi YADAVALLI , Sayantan PRADHAN , Sudesna CHAKRAVARTY
IPC: C09D11/52 , C09D11/037 , G01N33/543
Abstract: The technology is based on a conducting, ferromagnetic ink made from, in an aqueous suspension: conducting nanopolymers, ferromagnetic nanoparticles, an adhesion promoter and optionally, a surfactant and/or stabilizer. The ink is used to form reversible physical and electrical connections between e.g., rigid and flexible devices. In some aspects, the conducting nanopolymers are PEDOT:PSS (poly(3,4-ethylenedioxythiophene) polystyrene sulfonate) nanopolymers and the magnetic nanoparticles are iron oxide nanoparticles. The ink, which may be magnetic, is used to form solid, flexible, ferromagnetic conducting designs or nodes which may also be magnetic. The flexible, ferromagnetic conducting designs or nodes are used to form reversible magnetic electrical connections with devices such as potentiostats and data telemetry devices.
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公开(公告)号：US20240351222A1
公开(公告)日：2024-10-24
申请号：US18638895
申请日：2024-04-18
Applicant: Virginia Commonwealth University
Inventor： Logan Schorr , Ravi Hadimani , Bradley Johnson
CPC classification number: B25J15/08 , B22F12/88 , B22F12/90 , B33Y30/00 , B33Y50/02 , B33Y70/00 , B22F10/28 , B33Y10/00
Abstract: A robotic gripper is capable of withstanding the high temperatures of processes such as metal additive manufacturing. One or more of the fingers of the gripper include a casted ceramic insulator with a steel finger backing. Industrial thermocouples may attach to a finger for active temperature monitoring. An exemplary robotic gripper is adaptive, usable on a collaborative robot, and temperature resistant to over 1000° C. without introducing costly augmentations such as liquid cooling.
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公开(公告)号：US20240299520A1
公开(公告)日：2024-09-12
申请号：US18276140
申请日：2022-02-08
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Guizhi ZHU , Yu ZHANG
CPC classification number: A61K39/00119 , A61K39/001164 , A61K45/06 , A61P35/00 , C12N15/66 , C12Y101/01042 , A61K2039/53 , A61K2039/55555 , A61K2039/572
Abstract: Synthetic mini circular RNA vaccine constructs are provided. The synthetic mini circular RNA constructs encode one or more antigens and are used, for example, as vaccines against cancer or infectious agents. In some aspects, the one or more antigens are translated as concatemer peptides by rolling cycle translation (RCT) of the mini circular RNA.
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Patent Agency Ranking
公开(公告)号：US20240208984A1
公开(公告)日：2024-06-27
申请号：US18552761
申请日：2022-03-30
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Yan ZHANG
IPC: C07D489/08 , A61K9/19 , A61K31/485 , A61K47/55 , G01N33/68
CPC classification number: C07D489/08 , A61K9/19 , A61K31/485 , A61K47/55 , G01N33/6863
Abstract: Bivalent ligands which bind to MOR-CCR5 heterodimers are provided. The bivalent ligands comprise two discrete pharmacophores, naltrexone and maraviroc, linked by a spacer and bind to MOR-CCR5 heterodimers, e.g. at the surface of a cell. The bivalent ligands are useful in assays to detect MOR-CCR5 heterodimers, as therapeutic agents to prevent and/or treat diseases characterized by the presence of MOR-CCR5 heterodimers.
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公开(公告)号：US20240115572A1
公开(公告)日：2024-04-11
申请号：US18276574
申请日：2022-02-09
Inventor： Christopher RABENDER , Gene Chatman CLARK , Eleonora MEZZAROMA , Ross B. MIKKELSEN , Vasily YAKOVLEV , Neil SMITH
IPC: A61K31/519 , A61K9/00 , A61K31/495 , A61N5/00 , A61P35/00
CPC classification number: A61K31/519 , A61K9/0053 , A61K31/495 , A61N5/00 , A61P35/00
Abstract: The invention features methods of treating glioblastoma in a subject, the method comprising administering to the subject an effective amount of sepiapterin or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240077516A1
公开(公告)日：2024-03-07
申请号：US18446093
申请日：2023-08-08
Inventor： Jason REED , Andrey MIKHEYKIN , Loren PICCO , Oliver PAYTON , Freddie RUSSELL-PAVIER
CPC classification number: G01Q20/02 , C12N9/22 , C12N15/11 , C12Q1/683 , G01Q60/42 , C12N2310/20 , C12N2800/80 , C12Q2565/601
Abstract: Exemplary embodiments of the present disclosure can include, for example, an atomic force microscopy (AFM) system, including a cantilever(s), an optical pickup unit(s) (OPU(s)) including a laser positioned over the cantilever(s), and a power source providing noise with a noise level that is below 300 Picometers. The noise level of the power source can be below 200
Picometers. A digitizing arrangement can be included which can be associated with the OPU. The digitizing arrangement(s) can have a bandwidth of about 2 MHZ. The OPU(s) can have a detection bandwidth of at least 80 MHZ. The exemplary apparatus can be combined with a chemical protocol and statistical signal processing and image analysis procedures to map DNA at high speed and accuracy.-
公开(公告)号：US11918801B2
公开(公告)日：2024-03-05
申请号：US17519817
申请日：2021-11-05
Inventor： Jonathan Isaacs , Isaac Perry Clements , Andrew Willsie , James David Ross , Alex Weidenbach
CPC classification number: A61N1/0556 , A61B5/24 , A61B5/6877 , A61B5/6882 , A61N1/0558 , A61N1/36103
Abstract: An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue.
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公开(公告)号：US20240065430A1
公开(公告)日：2024-02-29
申请号：US18260658
申请日：2021-11-23
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Christina B. GORDON
CPC classification number: A46B15/0073 , A61C15/046 , A46B2200/108
Abstract: A combined flossing and interproximal brushing dental device, comprising: a handle having a proximal end and a distal end, wherein the proximal end is configured to be held by a user; a first arm; a second arm; dental floss engaging members positioned at or towards a free end of the first arm and at or towards a free end of the second arm, wherein said first arm and said second arm are spaced apart on the handle and the dental floss engaging members are configured to hold dental floss, extending between the first arm and the second arm; and an interproximal brush forming all or a part of the first arm.
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