- 专利标题： Polynucleotides encoding monoclonal antibodies binding to human pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1) and methods of making thereof
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申请号： US17558032申请日： 2021-12-21
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公开(公告)号： US11891435B2公开(公告)日： 2024-02-06
- 发明人: Neeraj Jagdish Agrawal , Kevin Graham , Agnes Eva Hamburger , Christopher Mohr , Derek E. Piper , Kenneth William Walker , Zhulun Wang , Cen Xu
- 申请人： AMGEN INC.
- 申请人地址： US CA Thousand Oaks
- 专利权人： AMGEN INC.
- 当前专利权人： AMGEN INC.
- 当前专利权人地址： US CA Thousand Oaks
- 代理商 Angela L. Purcell
- 分案原申请号： US16246326 2019.01.11
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; A61K39/395 ; A61K39/00 ; A61K49/00 ; A61K49/16 ; C12P21/08 ; G01N33/53 ; C07K16/18 ; C07K16/28 ; A61P25/06 ; A61K38/22 ; A61K47/68 ; A61K38/17 ; A61K51/10 ; C07K14/575 ; C07K16/26 ; C07K14/72 ; C07K14/47 ; G01N33/74 ; G01N33/68
摘要：
The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.
公开/授权文献
- US20220195022A1 PAC1 ANTIBODIES AND USES THEREOF 公开/授权日：2022-06-23
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