- Patent Title: Polynucleotides encoding monoclonal antibodies binding to human pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1) and methods of making thereof
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Application No.: US17558032Application Date: 2021-12-21
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Publication No.: US11891435B2Publication Date: 2024-02-06
- Inventor: Neeraj Jagdish Agrawal , Kevin Graham , Agnes Eva Hamburger , Christopher Mohr , Derek E. Piper , Kenneth William Walker , Zhulun Wang , Cen Xu
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agent Angela L. Purcell
- The original application number of the division: US16246326 2019.01.11
- Main IPC: C07K16/00
- IPC: C07K16/00 ; A61K39/395 ; A61K39/00 ; A61K49/00 ; A61K49/16 ; C12P21/08 ; G01N33/53 ; C07K16/18 ; C07K16/28 ; A61P25/06 ; A61K38/22 ; A61K47/68 ; A61K38/17 ; A61K51/10 ; C07K14/575 ; C07K16/26 ; C07K14/72 ; C07K14/47 ; G01N33/74 ; G01N33/68
Abstract:
The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.
Public/Granted literature
- US20220195022A1 PAC1 ANTIBODIES AND USES THEREOF Public/Granted day:2022-06-23
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