A process for synthesis of a waste-derived CO2-activated clinker, which comprises firing nodules at temperatures between 1000-1100° C. for a time sufficient to obtain CO2-reactive clinker phases within the nodules, cooling the clinker nodules, and reducing to powder to obtain a clinker powder; wherein the nodules are agglomerates of a stoichiometric mix of uniformly-sized powders of municipal solid waste (MSW) incineration residues; wherein the stoichiometric mix respects the primary compositional requisite of containing Ca, Al, and Si in their oxide forms within the ranges of 35-45 wt. % CaO, 2-8 wt. % AI2O3, and 12-20 wt. % SiO2; wherein the final stoichiometric mix has a total-sulfur content of 1 to 10 wt. %, total-carbon content of 2 to 20 wt. %, and a total-chlorine content of 2 to 15 wt. %.