发明授权
- 专利标题： Inactivation of pathogens in ex vivo blood products in storage bags using visible light
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申请号： US17750108申请日： 2022-05-20
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公开(公告)号： US11951217B2公开(公告)日： 2024-04-09
- 发明人: Chintamani Atreya , Michelle Maclean , John G. Anderson , Scott J. MacGregor
- 申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , The University of Strathclyde
- 申请人地址： US MD Bethesda
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services,University of Strathelyde
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services,University of Strathelyde
- 当前专利权人地址： US MD Bethesda; GB Glasgow
- 代理机构： Klarquist Sparkman, LLP
- 主分类号： A61L2/00
- IPC分类号： A61L2/00 ; A61L2/08
摘要：
Disclosed herein are methods and devices for the inactivation of pathogens (e.g., bacteria, viruses, etc.) in ex vivo stored blood products, such as plasma and/or platelets, by means of directing visible light radiation from an illuminating device into blood product storage containers in order to achieve effective pathogen inactivation without the presence of an added photosensitising agent in the blood product. An exemplary apparatus includes a control unit that operates a light source that emits light in the wavelength region of about 380-500 nm which is directed onto blood product storage bags at sufficient intensity to penetrate the bag material and the opaque blood product therein in order to inactivate pathogens in the blood product but at dose levels that cause no significant detrimental effects on the blood product.
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