Invention Grant
- Patent Title: Compositions and methods for treating diseases and disorders of the central nervous system
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Application No.: US16341704Application Date: 2017-10-16
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Publication No.: US11957713B2Publication Date: 2024-04-16
- Inventor: Alessandra Biffi , Marco Peviani , Davide Moscatelli , Alessia Capotondo , Rita Milazzo , Umberto Capasso Palmiero
- Applicant: CHILDREN'S MEDICAL CENTER CORPORATION , OSPEDALE SAN RAFFAELE S.R.L. , POLITECNICO DI MILANO , FONDAZIONE TELETHON ETS , DANA-FARBER CANCER INSTITUTE, INC.
- Applicant Address: US MA Boston
- Assignee: CHILDREN'S MEDICAL CENTER CORPORATION,OSPEDALE SAN RAFFAELE S.R.L.,POLITECNICO DI MILANO,FONDAZIONE TELETHON ETS,DANA-FARBER CANCER INSTITUTE, INC
- Current Assignee: CHILDREN'S MEDICAL CENTER CORPORATION,OSPEDALE SAN RAFFAELE S.R.L.,POLITECNICO DI MILANO,FONDAZIONE TELETHON ETS,DANA-FARBER CANCER INSTITUTE, INC
- Current Assignee Address: US MA Boston; IT Milan; IT Milan; IT Rome; US MA Boston
- Agency: Greenberg Traurig, LLP
- Agent Melissa Hunter-Ensor; Nathan Hsu
- International Application: PCT/US2017/056774 2017.10.16
- International Announcement: WO2018/071898A 2018.04.19
- Date entered country: 2019-04-12
- Main IPC: C12N5/071
- IPC: C12N5/071 ; A61K35/12 ; A61P25/28 ; C12N15/86 ; A01K67/0271 ; A61K9/00 ; A61K45/06
Abstract:
The present invention provides compositions and methods for the treatment or prevention of a neurological disease or disorder of the central nervous system (e.g., a storage disorder, lysosomal storage disorder, neurodegenerative disease, etc.) by reconstitution of brain myeloid cell and microglia upon transplantation of hematopoietic cells enriched in microglia reconstitution potential. The invention also provides compositions and methods for ablating and reconstituting microglia.
Public/Granted literature
- US20200038439A1 COMPOSITIONS AND METHODS FOR TREATING DISEASES AND DISORDERS OF THE CENTRAL NERVOUS SYSTEM Public/Granted day:2020-02-06
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