High-energy optical disinfection systems inside a commercial airplane using highly efficient, flexible, and durable side-emitting optical fibers optically coupled to high-energy UV-C laser diodes to destroy submicroscopic infectious agents and inactivate microorganisms inside the airplane. With the high-energy UV-C laser diodes optically coupled to the side-emitting optical fibers, which can be easily routed to different areas inside the airplane, the high-energy UV-C laser light emitted from the side of the optical fiber will disinfect the airplane along a wide or long swath continuously without interruption.