According to one or more of the embodiments herein, systems and techniques for multi-system-based detection and mitigation of Global Navigation Satellite System (GNSS) spoofing are provided. In one embodiment, a method comprises: obtaining a first location of an object from a primary location determination hardware system; obtaining a second location of the object from a secondary location determination hardware system; determining a distance difference between the first location and the second location; determining whether the distance difference between the first location and the second location is acceptable based on a threshold distance; and initiating one or more mitigation actions in response to the distance difference between the first location and the second location being unacceptable.