- 专利标题： Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
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申请号： US17063604申请日： 2020-10-05
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公开(公告)号： US11981922B2公开(公告)日： 2024-05-14
- 发明人: Meromit Singer , Aviv Regev , Orit Rozenblatt-Rosen , Davide Mangani , Ana Carrizosa Anderson , Vijay K. Kuchroo , Linglin Huang
- 申请人： Dana-Farber Cancer Institute, Inc. , The Broad Institute, Inc. , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc.
- 申请人地址： US MA Boston
- 专利权人： DANA-FARBER CANCER INSTITUTE, INC.,THE BROAD INSTITUTE, INC.,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- 当前专利权人： DANA-FARBER CANCER INSTITUTE, INC.,THE BROAD INSTITUTE, INC.,MASSACHUSETTS INSTITUTE OF TECHNOLOGY,THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- 当前专利权人地址： US MA Boston; US MA Cambridge; US MA Cambridge; US MA Boston
- 代理机构： Wenderoth, Lind & Ponack, L.L.P.
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; A61K39/395 ; C07K16/18 ; C07K16/22 ; C07K16/28 ; C07K16/38 ; C07K16/40 ; C12N5/0783 ; C12Q1/6886 ; A61K39/00
摘要：
The present invention is generally directed to identify interacting cells in the tumor microenvironment and using the identified interactions to enhance anti-tumor immunity in cancer. Identified interactions can be modulated using therapeutic agents. Immune cells resistant to suppression can be used for adoptive cell transfer. The present invention is also generally directed to cell types and genes that are correlated to time of tumor growth and tumor size.
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