专利检索 ap:("Dana-Farber Cancer Institute, Inc." OR "The Broad Institute, Inc." OR "Massachusetts Institute of Technology" OR "The Brigham AND Women's Hospital, Inc.") AND inv:"Davide Mangani" 第 1 页

1.

发明授权
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment 有权

公开(公告)号：US11981922B2

公开(公告)日：2024-05-14

申请号：US17063604

申请日：2020-10-05

申请人： Dana-Farber Cancer Institute, Inc. , The Broad Institute, Inc. , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc.

发明人： Meromit Singer , Aviv Regev , Orit Rozenblatt-Rosen , Davide Mangani , Ana Carrizosa Anderson , Vijay K. Kuchroo , Linglin Huang

IPC分类号： A61K35/17 , A61K39/395 , C07K16/18 , C07K16/22 , C07K16/28 , C07K16/38 , C07K16/40 , C12N5/0783 , C12Q1/6886 , A61K39/00

CPC分类号： C12N5/0638 , A61K35/17 , A61K39/39541 , A61K39/3955 , C07K16/18 , C07K16/22 , C07K16/2803 , C07K16/2818 , C07K16/2827 , C07K16/2863 , C07K16/2896 , C07K16/38 , C07K16/40 , C12Q1/6886 , A61K2039/507 , C07K2317/76 , C12Q2600/106

摘要： The present invention is generally directed to identify interacting cells in the tumor microenvironment and using the identified interactions to enhance anti-tumor immunity in cancer. Identified interactions can be modulated using therapeutic agents. Immune cells resistant to suppression can be used for adoptive cell transfer. The present invention is also generally directed to cell types and genes that are correlated to time of tumor growth and tumor size.

2.

发明申请
METHODS AND COMPOSITIONS FOR THE MODULATION OF OPIOID SIGNALING IN THE TUMOR MICROENVIRONMENT 有权

公开(公告)号：US20220105135A1

公开(公告)日：2022-04-07

申请号：US17494062

申请日：2021-10-05

申请人： The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc. , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc.

发明人： Meromit Singer , Aviv Regev , Orit Rozenblatt-Rosen , Davide Mangani , Ana Carrizosa Anderson , Vijay K. Kuchroo , Linglin Huang

IPC分类号： A61K35/17 , C07K16/28 , A61K45/06 , A61P35/00

摘要： The present invention is generally directed to identifying genes and cell types that are correlated with tumor progression in the tumor microenvironment. PENK was identified as a therapeutic target that is positively correlated with tumor time and size. Targeting PENK can enhance anti-tumor immunity. Opioid signaling can be modulated to enhance anti-tumor immunity. The present invention is also generally directed to interacting cells in the tumor microenvironment and using the identified interactions to enhance anti-tumor immunity in cancer. Identified interactions can be modulated using therapeutic agents. Immune cells resistant to suppression can be used for adoptive cell transfer.

3.

发明申请
METHODS AND COMPOSITIONS FOR THE MODULATION OF CELL INTERACTIONS AND SIGNALING IN THE TUMOR MICROENVIRONMENT 有权

公开(公告)号：US20210102168A1

公开(公告)日：2021-04-08

申请号：US17063604

申请日：2020-10-05

申请人： Dana-Farber Cancer Institute, Inc. , The Broad Institute, Inc. , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc.

发明人： Meromit Singer , Aviv Regev , Orit Rozenblatt-Rosen , Davide Mangani , Ana Carrizosa Anderson , Vijay K. Kuchroo , Linglin Huang

IPC分类号： C12N5/0783 , C07K16/28 , C07K16/22 , C07K16/38 , C07K16/18 , C07K16/40 , A61K39/395 , A61K35/17 , C12Q1/6886

摘要： The present invention is generally directed to identify interacting cells in the tumor microenvironment and using the identified interactions to enhance anti-tumor immunity in cancer. Identified interactions can be modulated using therapeutic agents. Immune cells resistant to suppression can be used for adoptive cell transfer. The present invention is also generally directed to cell types and genes that are correlated to time of tumor growth and tumor size.