The present invention discloses a Bluetooth mesh network system having wake-up management mechanism that includes a control node and low power nodes. The control node broadcasts a wake-up parameter setting packet at broadcast time spots based on a broadcast period. Each of the low power nodes receives the wake-up parameter setting packet to be operated in a wake-up management mode to configure a start time spot, a time length and a period interval length of a wake-up period that is synchronous among the low power nodes accordingly. The control node further transmits data corresponding to the low power nodes in the wake-up period and the low power nodes is operated in a wake-up state within the wake-up period to receive the data from the control node and is operated in a sleep state outside of the wake-up period.