- Patent Title: Low-viscosity antigen binding proteins and methods of making them
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Application No.: US17346156Application Date: 2021-06-11
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Publication No.: US11993663B2Publication Date: 2024-05-28
- Inventor: Joon Hoi Huh , Riki Stevenson , Pavel Bondarenko , Andrew Nichols , Da Ren , Neeraj Jagdish Agrawal , Richard Smith
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agent Melissa E. Karabinis
- The original application number of the division: US16338292
- Main IPC: C07K16/40
- IPC: C07K16/40 ; C07K16/28 ; G01N11/14
Abstract:
The present invention concerns a method for preparing antigen binding proteins specific for PCSK9 with reduced viscosity. The method proceeds by replacing residues in high viscosity variable domain subfamilies with residues in correlating low viscosity subfamilies. The method further comprises substituting residues in the Fc domain with residues associated with low viscosity and adding charged residues to the C-terminus of the Fc domain. The present invention further concerns antigen binding proteins produced by this method.
Public/Granted literature
- US20210371544A1 LOW-VISCOSITY ANTIGEN BINDING PROTEINS AND METHODS OF MAKING THEM Public/Granted day:2021-12-02
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