公开(公告)号：US11993663B2

公开(公告)日：2024-05-28

申请号：US17346156

申请日：2021-06-11

申请人： AMGEN INC.

发明人： Joon Hoi Huh ,  Riki Stevenson ,  Pavel Bondarenko ,  Andrew Nichols ,  Da Ren ,  Neeraj Jagdish Agrawal ,  Richard Smith

IPC分类号： C07K16/40 ,  C07K16/28 ,  G01N11/14

CPC分类号： C07K16/40 ,  C07K16/2869 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  G01N11/14

摘要： The present invention concerns a method for preparing antigen binding proteins specific for PCSK9 with reduced viscosity. The method proceeds by replacing residues in high viscosity variable domain subfamilies with residues in correlating low viscosity subfamilies. The method further comprises substituting residues in the Fc domain with residues associated with low viscosity and adding charged residues to the C-terminus of the Fc domain. The present invention further concerns antigen binding proteins produced by this method.

公开(公告)号：US20130197191A1

公开(公告)日：2013-08-01

申请号：US13738900

申请日：2013-01-10

申请人： AMGEN INC.

发明人： Richard Smith ,  Alice Bakker ,  Amy N Duguay ,  Peng Li ,  Yang Li

IPC分类号： C07K14/00

CPC分类号： C07K14/001 ,  A61K38/00 ,  C07K14/50 ,  C07K14/705 ,  C07K2319/70 ,  C07K2319/75

摘要： Binding proteins that specifically bind to β-Klotho or portions thereof, FGFR1c or portions thereof, or both FGFR1c and β-Klotho, and optionally other proteins as well are provided. Coding sequences, methods of treatment and pharmaceutical compositions are also provided.

摘要翻译： 提供了与β-Klotho或其部分特异性结合的结合蛋白，FGFR1c或其部分，或FGFR1c和β-Klotho以及任选的其它蛋白质。 还提供编码序列，治疗方法和药物组合物。