Invention Grant
- Patent Title: Non-chromatographic purification of macrocyclic peptides by a resin catch and release
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Application No.: US17943532Application Date: 2022-09-13
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Publication No.: US12018097B2Publication Date: 2024-06-25
- Inventor: Gardner S. Creech , Mahboubeh Kheirabadi , Martin D. Eastgate , David S. Nirschl , Percy H Carter
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agency: BakerHostetler
- The original application number of the division: US16618847
- Main IPC: C07C309/73
- IPC: C07C309/73 ; C07C309/07 ; C07C309/75 ; C07C309/77 ; C07D225/02 ; C07D225/08 ; C07K1/04 ; C07K1/107 ; C07K7/64 ; C07K17/08
Abstract:
The disclosure is directed to the synthesis and improved methods for purifying macrocyclic peptides produced by solid phase peptide synthesis. The synthesized peptide is capped with an alkyne-functionalized or azide-functionalized compound of formula (I):
prior to cleavage of the peptide from the solid phase support.
prior to cleavage of the peptide from the solid phase support.
Public/Granted literature
- US20240051996A1 NON-CHROMATOGRAPHIC PURIFICATION OF MACROCYCLIC PEPTIDES BY A RESIN CATCH AND RELEASE Public/Granted day:2024-02-15
Information query
