Patent search ap:("BRISTOL-MYERS SQUIBB COMPANY") AND inv:"Martin D. Eastgate" Page 1

1.

发明授权
Methods for the preparation of HIV attachment inhibitor piperazine prodrug compound 有权

公开(公告)号：US09403821B2

公开(公告)日：2016-08-02

申请号：US14516649

申请日：2014-10-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao

IPC: C07F9/02 , C07D471/04 , C07F9/6509

CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561

Abstract: A method for making the compound is set forth utilizing the starting material

2.

发明授权
Methods for the preparation of HIV attachment inhibitor piperazine prodrug compound 有权

公开(公告)号：US09376458B2

公开(公告)日：2016-06-28

申请号：US14516664

申请日：2014-10-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao

IPC: C07F9/09 , C07F9/6561 , C07D471/04 , C07C213/08 , C07F1/02 , C07D207/333 , C07D405/04

CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561

Abstract: A method for making the compound is set forth utilizing the starting material

3.

发明申请
METHODS FOR THE PREPARATION OF HIV ATTACHMENT INHIBITOR PIPERAZINE PRODRUG COMPOUND 有权

公开(公告)号：US20160108029A1

公开(公告)日：2016-04-21

申请号：US14516649

申请日：2014-10-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao

IPC: C07D471/04

CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561

Abstract: A method for making the compound is set forth utilizing the starting material

4.

发明授权
Methods for the preparation of HIV attachment inhibitor piperazine prodrug compound 有权
Title translation: 制备HIV附着抑制剂哌嗪前药化合物的方法

公开(公告)号：US08889869B2

公开(公告)日：2014-11-18

申请号：US13760526

申请日：2013-02-06

Applicant: Bristol-Myers Squibb Company

Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao

IPC: C07D471/04 , C07C213/08 , C07F9/6561

CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561

Abstract: A method for making the compound is set forth utilizing the starting material

Abstract translation: 使用原料制备化合物的方法

5.

发明授权
Process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrroldin-1-yl)cyclohexyl)acetamide 有权

公开(公告)号：US11254679B2

公开(公告)日：2022-02-22

申请号：US16631915

申请日：2018-07-19

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Burcu Selin Aytar , Alina Borovika , Collin Chan , Joerg Deerberg , Nathan R. Domagalski , Martin D. Eastgate , Yu Fan , Michael David Bengt Fenster , Robert V. Forest , Francisco Gonzalez-Bobes , Rebecca A. Green , Matthew R. Hickey , Nathaniel David Kopp , Thomas E. La Cruz , Kathleen Lauser , Hong Geun Lee , David K. Leahy , Helen Y. Luo , Thomas M. Razler , Scott A. Savage , Chris Sfouggatakis , Maxime C. D. Soumeillant , Serge Zaretsky , Bin Zheng , Ye Zhu

IPC: C07D487/04

Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.

6.

发明申请
PROCESS FOR THE PREPARATION OF N,N-DICYCLOPROPYL-4-(1,5-DIMETHYL-1H-PYRAZOL-3-YLAMINO)-6-ETHYL-1-METHYL-1,6-DIHYDROIMIDAZO[4,5-d]PYRROLO[2,3-b]PYRIDINE-7-CARBOXAMIDE 审中-公开
Title translation: 制备N，N-二异丙基-4-（1,5-二甲基-1H-吡唑-3-基氨基）-6-乙基-1-甲基-1,6-二氢吲哚并[4,5-d]吡咯的方法 [2,3-b]吡啶-7-羧酰胺

公开(公告)号：US20160229854A1

公开(公告)日：2016-08-11

申请号：US14914330

申请日：2014-08-28

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Martin D. Eastgate , Gregory L. Beutner , Benjamin Cohen , Nicolas Cuniere , Lopa V. Desai , Monica Fitzgerald , Qi Gao , Michael Bryan Hay , Michael Joseph Lawler , Paul C. Lobben , Christopher S. Regens , Thorsten Rosner , Neil Strotman , Carolyn S. Wei , Yi Xiao , Bin Zheng , Keming Zhu

IPC: C07D471/14 , C07D403/04 , C07D231/16 , C07D207/42

CPC classification number: C07D471/14 , C07D207/42 , C07D231/16 , C07D403/04

Abstract: The invention relates to an improved process for synthesizing N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide of the formula: (I) Compound (I) is currently in clinical trials for the treatment of myeloproliferative disorders, such as polycythaemia vera, thrombocythaemia and primary myelofibrosis.

Abstract translation: 本发明涉及一种合成N，N-二环丙基-4-（1,5-二甲基-1H-吡唑-3-基氨基）-6-乙基-1-甲基-1,6-二氢咪唑并[4,5 d]吡咯并[2,3-b]吡啶-7-甲酰胺，其化学式（I）化合物（I）目前正在临床试验中用于治疗骨髓增生性疾病，如多发性红血球病，血小板减少症和原发性骨髓纤维化。

7.

发明申请
METHODS FOR THE PREPARATION OF HIV ATTACHMENT INHIBITOR PIPERAZINE PRODRUG COMPOUND 审中-公开

公开(公告)号：US20160152644A1

公开(公告)日：2016-06-02

申请号：US14986816

申请日：2016-01-04

Applicant: Bristol-Myers Squibb Company

Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao

IPC: C07F9/6561 , C07C213/08

CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561

Abstract: A method for making the compound is set forth utilizing the starting material

8.

发明申请
PROCESS FOR THE PREPARATION OF 2-C-METHYL-D-RIBONIC-GAMMA-LACTONE 审中-公开
Title translation: 制备2-C-甲基-D-脯氨酸 - 乳液的方法

公开(公告)号：US20150126752A1

公开(公告)日：2015-05-07

申请号：US14407509

申请日：2013-06-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Sarah Evelyn Steinhardt , Martin D. Eastgate

IPC: C07D307/33

CPC classification number: C07D307/33

Abstract: Disclosed is a process to prepare a ribonolactone compound of Formula (I): comprising the step of reacting a fructosamine compound of Formula (II): in the presence of a calcium salt and a base in a nonaqueous reaction medium, to provide said ribonolactone compound of Formula (I).

Abstract translation: 公开了制备式（I）的核糖内酯化合物的方法：包括使式（II）的果糖胺化合物在钙盐和碱的存在下在非水反应介质中反应的步骤，以提供所述核糖内酯化合物的式（I）。