Techniques for encrypting data using a key generated by a physical unclonable function (PUF) are described. An apparatus according to the present disclosure may include decoder circuitry to decode an instruction and generate a decoded instruction. The decoded instruction includes operands and an opcode. The opcode indicates that execution circuitry is to encrypt data using a key generated by a PUF. The apparatus may further include execution circuitry to execute the decoded instruction according to the opcode to encrypt the data to generate encrypted data using the key generated by the PUF.