- 专利标题: Pseudo-electropherogram construction from peptide level mass spectrometry data
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申请号: US17828465申请日: 2022-05-31
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公开(公告)号: US12038444B2公开(公告)日: 2024-07-16
- 发明人: Andrew Nichols , Marshall Bern , Yong Joo Kil , Eric Carlson
- 申请人: Protein Metrics, LLC
- 申请人地址: US MA Boston
- 专利权人: Protein Metrics, LLC
- 当前专利权人: Protein Metrics, LLC
- 当前专利权人地址: US MA Boston
- 代理机构: Shay Glenn LLP
- 主分类号: G01N33/68
- IPC分类号: G01N33/68 ; H01J49/00
摘要:
Methods and apparatuses for the identification and/or characterization of properties of a macromolecule based on mass spectrometry data. Specifically, described herein are methods and apparatuses for converting peptide-level data into a pseudo-intact mass spectra. Also described herein are methods and apparatuses for converting peptide-level data into a pseudo-electropherogram. The methods may be well suited for analyzing proteins and protein complexes, including estimating properties of post-translational modifications of the proteins and protein complexes. Methods may include generating a theoretical graph or spectrum based on peptide-level mass spectrometry data. In some embodiments, the theoretical graph may be a theoretical intact mass spectrum or a theoretical charge distribution spectrum.
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